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DAT on Tranfusion Reaction Investigation


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    • By kaleigh
      Would anyone be willing to share their SOP's for "tubing" blood products? I am trying to get this started at my facility (even though it seems like everyone else has been doing it for years!) and am already getting lots of questions. I figure being able to explain what others do might help! Thank you in advance!
       
      Edit: we do not have the capability of "secure send" or scanning units/badges with our tube system
    • By SMILLER
      An interesting look at low verses high triggers for certain surgical patients.
      http://www.bloodjournal.org/content/early/2019/03/11/blood-2018-10-877530?sso-checked=true
      Scott
    • By Eagle Eye
      Hi all,
      Do you check microscopic reaction for all DAT?
      Do you use Ortho/Immucor/Other reagent?
      Do you receive specimen fro API/CAP for proficiency testing?
      Is there a requirement to check microscopic reaction / mixfield reaction?
      If yes, is this CAP/AABB/CLIA/other? \
      Thanks
    • By SusieQ132
      Our facility is evaluating making a change to our process for Weak D testing for patients with a positive DAT.  For years, if we were required to do a Weak D, but the patient had a positive DAT, we used to cancel the Weak D as invalid.  Another hospital in our system mentioned that they tended to perform the Weak D, but then only cancel as invalid if the Weak D is positive.  We are thinking about changing to this process, as we now have to result many babies as "Rh Unknown" and give their mothers Rhogam.  
      Per our Anti-D's package insert:  "Red blood cells coated with alloantibodies or autoantibodies of the same or similar specificity as the reagent (i.e. cells that are DAT positive) may give weak reactions. This is due to decreased availability of antigen sites because of antigen blocking or steric hinderance. In extreme cases false-negative results may occur." 
      I'm worried about the "extreme cases" where a false negative could occur, but I cannot see this being common.  Also, would you think that if the cells were coated with that much antibody, that we would see any other odd reactivity in the ABO/Rh?  What do other facilities do?
      Thank you in advance,
      Susan
    • By ejani
      I am sorry if this has been discussed previous... I searched and didn't find anything.  Quick question...
      We are transfusion service that performs DAT's using poly-clonal IgG... if it is positive, we run the mono-clonal IgG, however, we do not run the C3d.    How many of you would and/or do run the complement control cells for DAT QC in addition to Check Cells?  
       
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