Malcolm Needs
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Malcolm Needs's Achievements
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Malcolm Needs reacted to a post in a topic:
Homozygous Cells on Echo Panels
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jshepherd reacted to a post in a topic:
Homozygous Cells on Echo Panels
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Henrique reacted to a post in a topic:
Homozygous Cells on Echo Panels
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Malcolm Needs reacted to a post in a topic:
EUBIS Website.
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David Saikin reacted to a post in a topic:
Homozygous Cells on Echo Panels
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Erythrocytes cannot be either homozygous or heterozygous (or hemizygous for that matter). The terms homozygous, heterozygous and hemizygous should only be used when referring to genes, and, while antigens are (ultimately) derived from genes, many, such as A, B, H, I, i, Lea and Leb are not proteins, and cannot, therefore, be direct gene products (although even the "protein" antigens go through post-translational modification and so also cannot, strictly speaking, be direct gene products). On top of this, of course, the mature erythrocyte has exuded all nuclear material. Antigens, therefore, should only be referred to a single or double "dose".
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yan xia reacted to a post in a topic:
Severity of anti-Kpa HDFN
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Severity of anti-Kpa HDFN
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Ensis01 reacted to a post in a topic:
Severity of anti-Kpa HDFN
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Severity of anti-Kpa HDFN
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Severity of anti-Kpa HDFN
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Certainly this is what is recommended in the UK's BCSH (BSH) Guidelines (i.e. that they are referred to a foetal medicine unit for ultrasound monitoring) for any Kell-related antibody in pregnancy. I know this for a fact, as I was one of the co-authors!
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Malcolm Needs reacted to a post in a topic:
Severity of anti-Kpa HDFN
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Malcolm Needs reacted to a post in a topic:
Severity of anti-Kpa HDFN
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Arno reacted to a post in a topic:
Severity of anti-Kpa HDFN
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Severity of anti-Kpa HDFN
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Malcolm Needs reacted to a post in a topic:
Severity of anti-Kpa HDFN
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I do know of one case in the UK that involved an IUT given by Professor Kypros Nicolaides (a world renowned foetologist) at Kings College Hospital involving anti-Kpa in pregnancy, but I never saw it written up, and there was certainly no clinical sequalae, and so it could be that the anti-Kpa (the titre was not all that high) may well have been coincidental to some other pathological condition (KCH was one of "our" hospitals in terms of Red Cell Immunohaematology). In all my years in blood transfusion/blood group serology, I never saw an unequivocal case of anti-Kpa that caused clinically significant HDFN, and it was a fairly common antibody at our laboratory. That probably doesn't help that much, but that is my experience on the subject.
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RR1? Or possibly, Danny Gaskin, who is an authority on all things Blood Transfusion/Red Cell Immunohaematology/Quality - you name it, and if you don't, he will.
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Malcolm Needs reacted to a post in a topic:
transfusion of lipemic blood ????
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Sterile Connecting Device - Need Opinion
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Storing Saline Cubes
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Freezer -30C Thermometer uses sand instead of glyerol in bottle
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Malcolm Needs reacted to a post in a topic:
Storing Saline Cubes
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Welcome Medlabbie.
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Welcome Joerodz.
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Welcome olimolina.
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What you say has made me doubt it is anti-FORS1, as the FORS1 antigen is relatively rare in a human, so being positive with all five cases of group A would be highly unusual. I just wondered, but I think I am wrong. I doubt that it is Tn. It may be, but you can test this by using Dolichos biflorus, which would be positive with Tn activated red cells, while human-derived anti-A1 would be negative. Come what may, it is a VERY interesting case. THANK YOU for sharing it.
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Sorry to ask this yan xia, as I have great respect for your knowledge, but are you absolutely certain that it is anti-A (or anti-A1), and not a rare case of anti-FORS1?
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Welcome clippppp.
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Welcome Tim O'Neal.
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Welcome mgarner.
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I just answered this question. My Score PASS
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Welcome egayda.
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Welcome Martin.
