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Malcolm Needs

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Malcolm Needs last won the day on November 11

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About Malcolm Needs

  • Birthday 12/14/1954

Profile Information

  • Gender
    Male
  • Interests
    Rugby Union, Cricket, cooking, wine, port, reading, crosswords, lecturing, more wine and more port!
  • Biography
    Pretty boring really, but not that pretty!
  • Location
    Milverton, Somerset, England
  • Occupation
    I have taken a brand new role in the NHSBT and am now involved very much more on the education and training side of red cell immunohaematology. My title is still Reference Service Manager, but with Training after it (Reference Service Manager - Training). I am very excited about this change, as I have a passion for training and education.
    Reference Service Manager with the NHSBT.
    Chartered Scientist.
    Fellow of the British Blood Transfusion Society, having twice served on their National Council.
    Fellow of the Institute of Biomedical Science. Member of their Special Advisory Panel for Transfusion Science and Chief Examiner for Transfusion Science for the Institute.
    Author of the chapter "Human erythrocyte antigens or blood groups" in Fundamentals of Biomedical Science, Transfusion and Transplantation Science, edited by Robin Knight, for the IBMS. 1st edition, Oxford University Press 2013 (ISBN 978-0-19-953328-2, pages 19-44.
    Just been appointed to the BCSH Blood Transfusion Task Force (writing Guidelines).
    Member of ISBT and AABB
    I am now retired from the Blood Service, but still do the other things!
  • Real Name
    Malcolm Needs CSci FIBMS FBBTS

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Community Answers

  1. Malcolm Needs
    Welcome JJBBANK1.
  2.    Henrique reacted to a post in a topic: Can I get your opinion or insight on this? Thank you.
  3. Malcolm Needs
    Welcome bryony.ar.
  4. Malcolm Needs
    Welcome SpaKopasoula.
  5.    AMcCord reacted to a post in a topic: Antibody Screen Tube method
  6.    David Saikin reacted to a post in a topic: Can I get your opinion or insight on this? Thank you.
  7.    sdarmor1 reacted to a post in a topic: Unidentified Antibody, Little Help Please
  8.    yan xia reacted to a post in a topic: Can I get your opinion or insight on this? Thank you.
  9. Malcolm Needs
    I cannot see why they would be expressed as histoantigens if they did not have a function, but, apart from causing problems with some organ transplants, I am a bit foxed as to what the function may be.
  10.    diplomatic_scarf reacted to a post in a topic: Can I get your opinion or insight on this? Thank you.
  11.    diplomatic_scarf reacted to a post in a topic: Newly detected anti-D
  12. Malcolm Needs
    Welcome CarlaDFW.
  13. Malcolm Needs
    Welcome Rosemary Taylor.
  14.    Malcolm Needs reacted to a post in a topic: Jobs Section
  15.    Malcolm Needs reacted to a post in a topic: Professor David Anstee.
  16.    AMcCord reacted to a post in a topic: Can I get your opinion or insight on this? Thank you.
  17. Malcolm Needs
    Welcome 1360464107@qq.com.
  18.    AMcCord reacted to a post in a topic: Professor David Anstee.
  19.    Malcolm Needs reacted to a post in a topic: Time from Issue to start of transfusion
  20.    Malcolm Needs reacted to a post in a topic: Time from Issue to start of transfusion
  21.    Malcolm Needs reacted to a post in a topic: No Patient Registration
  22.    Malcolm Needs reacted to a post in a topic: Professor David Anstee.
  23.    Malcolm Needs reacted to a post in a topic: Pre-Transfusion Two-Blood Group Policy
  24.    Ensis01 reacted to a post in a topic: Calculating the Frequency for finding antigen negative unit
  25. Malcolm Needs
    Excellent - in theory!
  26.    Malcolm Needs reacted to a post in a topic: Professor David Anstee.
  27.    Malcolm Needs reacted to a post in a topic: Professor David Anstee.
  28.    Malcolm Needs reacted to a post in a topic: Professor David Anstee.
  29. Malcolm Needs
    Welcome to this wonderful site LindsayLajiness.
  30. Malcolm Needs
    It is with enormous sadness that I have to tell you that, having just arrived back from a short break, I have been informed of the death of Prof. Dave Anstee - one of the greats of the world of Blood Transfusion and Blood Group Serology. I am devastated.
  31. Kb913 started following Malcolm Needs
  32. Malcolm Needs
    No idea, I am afraid.
  33. Malcolm Needs
    Not so in the UK. ALL of our units are typed for the D, C, c, E, e and K antigens, as well as (obviously) ABO and mandatory viral markers. However, those that are intended for patients with atypical antibodies will come from a store of units that are further "fully typed" (usually from the MNS to the Kidd BGS) and these tend to be all K Negative, as they are intended for individuals who have already shown themselves to be "responders", most of whom will be K Negative, and K is a highly immunogenic antigen (although, of course, those intended for individuals with anti-k will be K Positive and k Negative!). The number of these typed units is not, however, immense, and so does not really "skew" the overall antigen frequency in the normal stock.
  34. Malcolm Needs
    Guidelines for pre‐transfusion compatibility procedures in blood transfusion laboratories - - 2013 - Transfusion Medicine - Wiley Online Library This is a link to the UK Guideline that talks about two samples being typed. All of the BSH Guidelines are evidence-based.
  35. Malcolm Needs
    In terms of the function of the various ABO blood types, there have been a huge number of peer-reviewed papers written on the subject (and the number has exploded with the advent of COVID19). I would seriously defy anyone to keep up with all of these, but I would recommend reading pages 42-43 of Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook. 3rd edition, 2012. Academic Press. ISBN: 978-0-12-415849-8. In terms of how they evolved, it is so far back now that it is anyone's guess, but slides 28 to 32 of the attached lecture may give you some idea. In Depth Lecture on The ABO and H Blood Group Systems.pptx
  36. Malcolm Needs
    In some plasma components, it would undoubtedly be residual D positive red cells, as long as the component has not been frozen, as the freezing and thawing process would disrupt the structure of the membrane (although some people have theorised that the D antigen on disrupted red cell membranes may still cause sensitisation [I don't believe it]). However, once anti-D has been produced by a person, it takes minute amounts of D positive red cells to cause a strong secondary production (see around and about slide 60 of the attached lecture - which I know is about HDFN, but the sensitisation is the same). In Depth Lecture on Alloimmune Haemolytic Disease of the Foetus and Newborn HDFN.pptx
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