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Malcolm Needs

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Malcolm Needs last won the day on November 11

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About Malcolm Needs

  • Birthday 12/14/1954

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  • Gender
  • Interests
    Rugby Union, Cricket, cooking, wine, port, reading, crosswords, lecturing, more wine and more port!
  • Biography
    Pretty boring really, but not that pretty!
  • Location
    Milverton, Somerset, England
  • Occupation
    I have taken a brand new role in the NHSBT and am now involved very much more on the education and training side of red cell immunohaematology. My title is still Reference Service Manager, but with Training after it (Reference Service Manager - Training). I am very excited about this change, as I have a passion for training and education.
    Reference Service Manager with the NHSBT.
    Chartered Scientist.
    Fellow of the British Blood Transfusion Society, having twice served on their National Council.
    Fellow of the Institute of Biomedical Science. Member of their Special Advisory Panel for Transfusion Science and Chief Examiner for Transfusion Science for the Institute.
    Author of the chapter "Human erythrocyte antigens or blood groups" in Fundamentals of Biomedical Science, Transfusion and Transplantation Science, edited by Robin Knight, for the IBMS. 1st edition, Oxford University Press 2013 (ISBN 978-0-19-953328-2, pages 19-44.
    Just been appointed to the BCSH Blood Transfusion Task Force (writing Guidelines).
    Member of ISBT and AABB
    I am now retired from the Blood Service, but still do the other things!
  • Real Name
    Malcolm Needs CSci FIBMS FBBTS

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  1. I cannot see why they would be expressed as histoantigens if they did not have a function, but, apart from causing problems with some organ transplants, I am a bit foxed as to what the function may be.
  2. Welcome to this wonderful site LindsayLajiness.
  3. It is with enormous sadness that I have to tell you that, having just arrived back from a short break, I have been informed of the death of Prof. Dave Anstee - one of the greats of the world of Blood Transfusion and Blood Group Serology. I am devastated.
  4. Not so in the UK. ALL of our units are typed for the D, C, c, E, e and K antigens, as well as (obviously) ABO and mandatory viral markers. However, those that are intended for patients with atypical antibodies will come from a store of units that are further "fully typed" (usually from the MNS to the Kidd BGS) and these tend to be all K Negative, as they are intended for individuals who have already shown themselves to be "responders", most of whom will be K Negative, and K is a highly immunogenic antigen (although, of course, those intended for individuals with anti-k will be K Positive and k Negative!). The number of these typed units is not, however, immense, and so does not really "skew" the overall antigen frequency in the normal stock.
  5. Guidelines for pre‐transfusion compatibility procedures in blood transfusion laboratories - - 2013 - Transfusion Medicine - Wiley Online Library This is a link to the UK Guideline that talks about two samples being typed. All of the BSH Guidelines are evidence-based.
  6. In terms of the function of the various ABO blood types, there have been a huge number of peer-reviewed papers written on the subject (and the number has exploded with the advent of COVID19). I would seriously defy anyone to keep up with all of these, but I would recommend reading pages 42-43 of Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook. 3rd edition, 2012. Academic Press. ISBN: 978-0-12-415849-8. In terms of how they evolved, it is so far back now that it is anyone's guess, but slides 28 to 32 of the attached lecture may give you some idea. In Depth Lecture on The ABO and H Blood Group Systems.pptx
  7. In some plasma components, it would undoubtedly be residual D positive red cells, as long as the component has not been frozen, as the freezing and thawing process would disrupt the structure of the membrane (although some people have theorised that the D antigen on disrupted red cell membranes may still cause sensitisation [I don't believe it]). However, once anti-D has been produced by a person, it takes minute amounts of D positive red cells to cause a strong secondary production (see around and about slide 60 of the attached lecture - which I know is about HDFN, but the sensitisation is the same). In Depth Lecture on Alloimmune Haemolytic Disease of the Foetus and Newborn HDFN.pptx
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