Jump to content

Malcolm Needs

Premium Members
  • Content count

  • Joined

  • Last visited

  • Days Won

  • Country

    United Kingdom

Malcolm Needs last won the day on June 15

Malcolm Needs had the most liked content!

About Malcolm Needs

  • Rank
    Seasoned poster
  • Birthday 12/14/1954

Profile Information

  • Gender
  • Interests
    Rugby Union, Cricket, cooking, wine, port, reading, crosswords, lecturing, more wine and more port!
  • Biography
    Pretty boring really, but not that pretty!
  • Location
    Croydon, Surrey, England
  • Occupation
    I have taken a brand new role in the NHSBT and am now involved very much more on the education and training side of red cell immunohaematology. My title is still Reference Service Manager, but with Training after it (Reference Service Manager - Training). I am very excited about this change, as I have a passion for training and education.
    Reference Service Manager with the NHSBT.
    Chartered Scientist.
    Member of the British Blood Transfusion Society, having twice served on their National Council.
    Fellow of the Institute of Biomedical Science. Member of their Special Advisory Panel for Transfusion Science and Chief Examiner for Transfusion Science for the Institute.
    Author of the chapter "Human erythrocyte antigens or blood groups" in Fundamentals of Biomedical Science, Transfusion and Transplantation Science, edited by Robin Knight, for the IBMS. 1st edition, Oxford University Press 2013 (ISBN 978-0-19-953328-2, pages 19-44.
    Just been appointed to the BCSH Blood Transfusion Task Force (writing Guidelines).
    Member of ISBT and AABB.
    I am now retired from the Blood Service, but still do the other things!
    Got bored with being retired, and so am doing locum work in Blood Transfusion at St. Richard's Hospital in Chichester, West Sussex (and thoroughly enjoying myself!).

Recent Profile Visitors

7,937 profile views
  1. Malcolm Needs

    Welcome NikkiHCLS

    Welcome NikkiHCLS.
  2. Malcolm Needs

    Welcome hmh

    Welcome hmh.
  3. Malcolm Needs

    Welcome Ranju

    Welcome Ranju.
  4. Malcolm Needs

    Welcome Shmoops

    Welcome Shmoops.
  5. Malcolm Needs


    As Rh grouping reagents are, these days, almost, if not absolutely, monoclonal IgM antibodies, and therefore, not affected by a positive DAT, one wonders under what situation this would pertain, unless the mother was D Negative and the antibody causing the baby's DAT was positive. If this were so, why would you not be able to use the results of the IgM monoclonal reagents? If, for some reason you could not (the reason why escapes me), you could treat the red cells with chloroquine (although this , in itself, weakens the Rh antigen expression), or, of course, you could give anti-D immunoglobulin anyway, and assume that the baby is D Positive, with no evidence whatsoever, and expose the mother to 1) a human-derived antibody, which may be carrying a virus that has yet to be recognised, that they almost certainly do not require, and 2) a human-derived antibody that may cause a severe reaction due to, for example, anti-IgA, I really WOULD advise that you rely on the results you get with IgM grouping reagents, and stop worrying about the tiny chances that there would be clinical sequelae, and I (seriously) would advise the likes of the FDA do the same!
  6. Malcolm Needs

    wAIHA with IgM and C3c/C3d coating

    What would be really helpful, and is quite simple, is to treat the plasma with 0.01M DTT (or ZZAP come to that), which will denature IgM molecules by breaking the J-chains. This will show if the antibody is IgM or not. Do not forget that some IgG antibodies can cause agglutination in the "cold" and the "warm", with no potentiating agents being present, so it is worth knowing, from the word "Go", with what you are dealing.
  7. Malcolm Needs

    Welcome 1freshginger

    Welcome 1 freshginger.
  8. Malcolm Needs

    Welcome Jalene

    Welcome Jalene.
  9. Malcolm Needs

    Welcome Kathleen B

    Welcome Kathleen B.
  10. Malcolm Needs

    IgM antibody and Neo analyser

    Indeed not, but it would be detected in many cases.
  11. Malcolm Needs

    IgM antibody and Neo analyser

    It wouldn't be missing those specificities that would worry me so much as missing an anti-Vel. Such antibodies are extremely rare. Such antibodies are also extremely clinically significant.
  12. Malcolm Needs

    RHIG stored at room temperature for hours

    Fair comment John, not fatal septicaemia, just fatal cellulitis! My point was though, that it is just not worth taking the risk.
  13. Malcolm Needs

    AntiD +Anti G

    If you go to the Library Section of this site, Educational Material, second page Allo-Immune Haemolytic Disease of the Fetus and Newborn (HDF / HDN), and look at slides 45 to 60, you will see photographs of the continuous flow analysers sued within the NHSBT to perform quantification of anti-D and anti-c. These photographs are of one of our older machines, as it allows you to see what is going on, whereas the newer machines are enclosed in the ubiquitous "black box", so you wouldn't be able to see anything. Attached is a Word document that, I hope, explains the photographs. Alloimmune Haemolytic Anaemia and Disease of the Foetus.doc
  14. Malcolm Needs

    Welcome LAB216

    Welcome LAB216.
  15. Malcolm Needs

    antibody identification art or science

    I've put this right since BankerGirl!

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.