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Malcolm Needs

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Malcolm Needs last won the day on May 25

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About Malcolm Needs

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  • Gender
  • Interests
    Rugby Union, Cricket, cooking, wine, port, reading, crosswords, lecturing, more wine and more port!
  • Biography
    Pretty boring really, but not that pretty!
  • Location
    Milverton, Somerset, England
  • Occupation
    I have taken a brand new role in the NHSBT and am now involved very much more on the education and training side of red cell immunohaematology. My title is still Reference Service Manager, but with Training after it (Reference Service Manager - Training). I am very excited about this change, as I have a passion for training and education.
    Reference Service Manager with the NHSBT.
    Chartered Scientist.
    Fellow of the British Blood Transfusion Society, having twice served on their National Council.
    Fellow of the Institute of Biomedical Science. Member of their Special Advisory Panel for Transfusion Science and Chief Examiner for Transfusion Science for the Institute.
    Author of the chapter "Human erythrocyte antigens or blood groups" in Fundamentals of Biomedical Science, Transfusion and Transplantation Science, edited by Robin Knight, for the IBMS. 1st edition, Oxford University Press 2013 (ISBN 978-0-19-953328-2, pages 19-44.
    Just been appointed to the BCSH Blood Transfusion Task Force (writing Guidelines).
    Member of ISBT and AABB
    I am now retired from the Blood Service, but still do the other things!
  • Real Name
    Malcolm Needs CSci FIBMS FBBTS

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  1. Erythrocytes cannot be either homozygous or heterozygous (or hemizygous for that matter). The terms homozygous, heterozygous and hemizygous should only be used when referring to genes, and, while antigens are (ultimately) derived from genes, many, such as A, B, H, I, i, Lea and Leb are not proteins, and cannot, therefore, be direct gene products (although even the "protein" antigens go through post-translational modification and so also cannot, strictly speaking, be direct gene products). On top of this, of course, the mature erythrocyte has exuded all nuclear material. Antigens, therefore, should only be referred to a single or double "dose".
  2. Certainly this is what is recommended in the UK's BCSH (BSH) Guidelines (i.e. that they are referred to a foetal medicine unit for ultrasound monitoring) for any Kell-related antibody in pregnancy. I know this for a fact, as I was one of the co-authors!
  3. I do know of one case in the UK that involved an IUT given by Professor Kypros Nicolaides (a world renowned foetologist) at Kings College Hospital involving anti-Kpa in pregnancy, but I never saw it written up, and there was certainly no clinical sequalae, and so it could be that the anti-Kpa (the titre was not all that high) may well have been coincidental to some other pathological condition (KCH was one of "our" hospitals in terms of Red Cell Immunohaematology). In all my years in blood transfusion/blood group serology, I never saw an unequivocal case of anti-Kpa that caused clinically significant HDFN, and it was a fairly common antibody at our laboratory. That probably doesn't help that much, but that is my experience on the subject.
  4. RR1? Or possibly, Danny Gaskin, who is an authority on all things Blood Transfusion/Red Cell Immunohaematology/Quality - you name it, and if you don't, he will.
  5. What you say has made me doubt it is anti-FORS1, as the FORS1 antigen is relatively rare in a human, so being positive with all five cases of group A would be highly unusual. I just wondered, but I think I am wrong. I doubt that it is Tn. It may be, but you can test this by using Dolichos biflorus, which would be positive with Tn activated red cells, while human-derived anti-A1 would be negative. Come what may, it is a VERY interesting case. THANK YOU for sharing it.
  6. Sorry to ask this yan xia, as I have great respect for your knowledge, but are you absolutely certain that it is anti-A (or anti-A1), and not a rare case of anti-FORS1?
  7. I just answered this question. My Score PASS  
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