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Arno

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    Switzerland

Arno last won the day on July 17 2022

Arno had the most liked content!

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  • Gender
    Male
  • Occupation
    Scientist with more than 20 years of experiences in blood banks, transfusion centers, hospitals and national health authority. I believe we share a common passion for Immunohematology and for the moment I do work for a private company in Switzerland as scientific affairs manager.

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  1. I just answered this question. My Score PASS  
  2. I just answered this question. My Score PASS  
  3. I just answered this question. My Score PASS  
  4. Hi! Should it rather be "ex-vivo" in the question? I got confused...
  5. I just answered this question. My Score FAIL  
  6. I just answered this question. My Score PASS  
  7. There was no recording in these "good old days" unfortunately. I had the chance to spend a few days with Sue some weeks ago (we were lecturing at the same event) and I should say that on the top of what Malcolm wrote which is very true, she is such a wonderful person, as Malcolm is!
  8. The most likely answer has been given above: newly formed autologous red cells have a lower gravity than transfused cells and will concentrate at the top of the re cell pellet whereas transfused cells will seat at the bottom. I hereby attach a paper describing that phenomenon. I hope Grifols will thank you for giving them the answer :-) 20230301142735376.pdf20230301142735376.pdf
  9. Wanted to say... anti-human IgG of course and not human anti-IgG..... sorry for that. I use the opportunity to add that AHG card should have a slightly green colored gel (based on similar products available in Europe) whereas the neutral-saline should be transparent.
  10. Hi Clarest, I am not familiar with the MTS product line, but to me it says that enzyme treated cells can be used in AHG card (the human anti-IgG is already in the gel card of course) though you may experience some non specific reactions plus a higher detection rate of unclinically significant antibodies (specific but unwanted...). This uses (enzyme + AHG), as mentionned above, should be well understood/assessed/validated/targeted => you will as well enhance the reactivities for other clinically significant antibodies such as anti-Jka which is the purpose. Then, they rather recommend to use these enzyme treated cells in their "neutral-saline" cards (called buffered gel), which does not contain AHG. It is propably a way to prevent you to complain if you get an increase of positive reactions to be further investigated whereas this is mostly due to unclinically significant antibodies. Enzyme reactive antibodies (e.g. anti-Rh) are "expected" (why antibodies do no read IH books...) to agglutinate in neutral-saline cards as ABO agglutinins do, without AHG. Having said that, anti-Jka are better detected in coombs + enzyme ....
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