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John C. Staley

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Posts posted by John C. Staley

  1. 13 hours ago, RRay said:

    I often wonder how certain practices got started.

    Someone one time tried something once and achieved the results they were looking for and told someone else.......  That's usually how it appears to work and in all my years working in blood banks and transfusion services I have discovered that inertia is the most powerful force in the universe!

    :coffeecup:

  2. 23 hours ago, Malcolm Needs said:

    That is true John, BUT it is STILL the complement (specifically the Membrane Attack Complex of C5b, activated C6, C7 and C8 molecules and about 6 activated C9 molecules) that causes the haemolysis, which is why autologous red cells are also destroyed.

    Malcolm we can do this for ever!!  The antibodies CAUSE the hemolysis by activating the compliment. 

    Here's my analogy, without my finger pulling the trigger the gun doesn't go off and I don't get a bird in the bag. When I do pull the trigger did I kill the bird or did the lead shot kill the bird?  Or did the gun kill the bird? To address the hemolysis of autologous cells with the same analogy. Occasionally 2 birds are close together and both are killed with the same shot.  One was intended the other was not but I still pulled the trigger.  

    Take one of the factors out of the equation and the end result does not happen or is significantly altered so the answer to all the questions is YES.  I think what we have here is a case of semantics.  Every step could be said to have CAUSED the end result.  

    This is fun.  Let's discuss it over a pint some day.

    :coffeecup:

  3. 21 hours ago, Malcolm Needs said:

    Sorry, but I disagree.  In most cases of ABO haemolytic transfusion reactions, it is not the ABO antibodies that cause the haemolysis that destroys the incompatible red cells, but activated complement that, in most cases, also causes "innocent bystander haemolysis", whereby the autologous red cells are also haemolysed.

    I may be mistaken but I seem to recall being taught that it was the ABO antibodies interaction with incompatible RBCs which caused the activated complement so without the ABO antibodies you don't get the hemolysis.

  4. To my knowledge, there has never been such a rule, regulation or requirement (the 3 "Rs" that rule the blood bank).  In two blood banks / transfusion services I worked in, one was in a separate room but certainly big enough.  In the other, we were part of the lab but separated from the rest of the lab in the same way chemistry was separate from hematology.  The only department that had it's own room was microbiology.

    :coffeecup:

  5. On 9/28/2022 at 6:24 AM, AMcCord said:

    I would upgrade both of my blood storage refrigerators to the Helmer i-series and set them up for downloading temps so less paper trail. I would bring in a new Echo (ours is upgraded, but old). I would remodel Blood Bank (knock out a wall) to give us a little more room and a more ergonomically friendly space to work, maybe add another spot to flex to workspace for MTP events and for our students. Actually, I want a whole new Blood Bank with more room and windows! I don't want much really............

    At my last large facility they built a new hospital (we moved in in March 2002).  Lab supervisors were able to design their section.  As a fluke I put windows in my design.  I was shocked when, on our first walk through the Transfusion service actually had windows!!!  Wish I had put a couple in my office!

  6. Malcolm, my very 1st AABB inspection came about 2 months after taking the Blood Bank supervisor job.  After it was over I contacted AABB and told them that I would never let that inspector in my facility again and if they tried to send her I would drop our AABB membership.  YES, the inspection/inspector was really that bad and luckily I never had to carry through with my threats/promises.  

    :coffeecup:

  7. 17 hours ago, Cliff said:

    I'd be in favor of keeping both CAP and AABB.

    If one of them is doing your CMS inspection, then the other can be used as "practice".

    Personally, I never minded inspections/assessments.  My blood bank and transfusion service were "visited" no less than twice every year by inspectors.  Either FDA (we were licensed to ship blood interstate at one facility I supervised), AABB, CAP or JCHO.  Being inspected that often meant we never had the opportunity to let things slip unlike other areas of the lab that were inspected less frequently.  On the other hand it did become very expensive paying memberships as well as buying materials required to stay current on the requirements of each agency.  When cost cutting measures were called for reducing in this area was always discussed but for some reason was never acted upon.

    :coffeecup:

     

  8. A number of years ago in a meeting of the corporate transfusion service supervisors we discussed the possibility of dropping our AABB membership.  After much discussion the corporate transfusion service medical director decided that we would not be dropping the AABB membership.  Her reasoning, the prestige of being in charge of a group of facilities fully accredited by AABB was very important to her.  She actually told us that!

    :coffeecup:

  9. I'm curious, can those 25% that appear to be "order abuse" be linked to specific docs or is it random through out the ED?  With current computer technology this should be discoverable.  Over the years of my career I realized that not all ED docs are created equal and some have a much lower threshold for CYA than others.  Just a random thought.

    :coffeecup:

  10. 23 hours ago, Malcolm Needs said:

    Yes John,  With higher dose anti-D immunoglobulin, the DAT of a D Positive baby is quite often positive.  In the UK it is now quite common to give a dose of 1, 500 IU of anti-D immunoglobulin at 28 weeks of gestation and, as a result, many babies have a positive DAT, but I have never heard of clinically significant HDFN as a result,  Physiological jaundice is also quite common in newborns, whether the mother was given anti-D immunoglobulin or not, and whether the baby is D Positive or D Negative.

    What I was trying to get at is if the DAT is negative and the antibody screen is negative why would anyone consider it necessary to provide D negative red cells.   Another thought/question just occurred to me (odd, I know), why are they transfusing the baby?  Is it due to excessive blood draws or is the a hemolytic process going on?  That would make a difference as well.

  11. 21 hours ago, TMGal said:

     The lab is staffed 24/7 so if the equipment alarms in the lab, it would be heard and attended to. 

    So, why, pray tell, does the alarm even sound at a nursing desk?  This is quite unnecessary and obviously inconvenient for all involved.  If the reason is, as usual, "that's the way be been as long as anyone remembers", it's time for a change.  Hopefully you can get this easily rectified.  Good luck.

    :coffeecup:

  12. I'm curious on what you consider a 3rd party outside the lab.  The engineering department within the hospital could be considered a 3rd party out side the lab but I personally would consider them acceptable because they could react immediately to the alarms.  If you are referring to someone far outside the facility that would be considered a subcontractor I would be hesitant to consider this acceptable but that's just my opinion.

    :coffeecup:

  13. On 5/13/2022 at 8:53 AM, David Saikin said:

    I QC reagents before I put them into use; usually not upon receipt.

    Just a thought but, might that not be a little problematic if there is an issue with the reagents? 

    I know it's one of those "what if" questions that never happens but I couldn't help my self.  To be honest, it's been long enough I don't remember what we did but something tickles the back of my brain making me think we did some form of on receipt QC but I'm certain it was not overly extensive or burdensome.

    :coffeecup:

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