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Please be sure to recruit the brother as blood donor as he is a valuable donor.

Hi Malcolm, I am a new member and just read this topic and I like to say that is honorable to be recognized for your contributions to transfusion medicine. It is exciting no need for apology Very glad I joined the society of transfusion medicine.

Malcolm is awesome - I found my first anti-f a few years ago and he made cogent comments similar to yours. He is a great resource.

Thanks. That, at least, makes it even more likely. I would suggest that, at some point, she has either been transfused with blood expressing the RHCE*ce haplotype, or has been pregnant before with a foetus expressing this haplotype. The good news is that, if it proves to actually be anti-f, it has only ever been implicated in cases of mild, almost sub-clinical, HDFN.

Malcolm, thanks so much for the article. It was very helpful. As it turned out, we sent mom's sample to our reference lab for MMA testing, and we also antigen typed her 2 brothers and her father. One of the brothers matched her Duffy and Kidd antigen types and was Coombs crossmatch compatible with her. He donated two units of packed red cells (at one donation) and was also confirmed to be Diego b negative. The patient's anti-Dib came back as clinically significant based on the MMA test. She did have a C-section after all and did not require any blood! The baby had a negative direct coombs so there were no issues there either!

The antibodies didn't read our books???