Minerva, I'm not sure I will be able to explain my logic here, but I'll try......Here we go... You thaw the FFP and put in in a cooler with adequate ice (or some type of appropriate cool-pack) in a validated cooler. If they return the unused FFP within a reasonable time (say an hour or 2), isn't it reasonable that the cooler temp may be out of the proper range just because the 37C FFP is on its way to cooling down? If that's the case, the FFP is just as safe to use as the 37C FFP that you thawed and placed in your blood refrigerator until it expires in 24 hours (or 5 days, depending on your policy.) However, if the FFP in the cooler is warmer than the acceptable temperature range because there was not adequate ice (or coolant) to get and keep the FFP within the proper temperature range, then I would consider it unacceptable to return the FFP to the Blood Bank/Transfusion Service for reissue and I would destroy the unit. (Example: If the FFP is returned 6 hours later and it is 13C, I would destroy it.) Exactly how long does it take the thawed 37C FFP to come down to 6C? You will find out when you thaw some FFP and do your cooler validation. Donna