SMILLER Posted November 20, 2012 Share Posted November 20, 2012 You have a gel screen/panel that shows a clear pattern for M showing dosage. You run it in 30 minute inc saline tube, all negative. The patient has no history of transfusion -- so apparently this is a naturally occuring anti-M, or possible a cold showing M reactivity.What next if one wants to crossmatch a couple of units?Thanks, Scott Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 20, 2012 Share Posted November 20, 2012 In the UK, we would give cross-match compatible blood (not typed to be M-) if the anti-M does not react strictly at 37oC, in line with Daniels G, Poole J, de Silva M, Callaghan T, MacLennan, S, Smith N. The clinical significance of blood group antibodies. Transfusion Medicine 2002; 12: 287-295. Link to comment Share on other sites More sharing options...
R1R2 Posted November 20, 2012 Share Posted November 20, 2012 In the UK, we would give cross-match compatible blood (not typed to be M-) if the anti-M does not react strictly at 37oC, in line with Daniels G, Poole J, de Silva M, Callaghan T, MacLennan, S, Smith N. The clinical significance of blood group antibodies. Transfusion Medicine 2002; 12: 287-295.I agree with Malcolm Link to comment Share on other sites More sharing options...
dcubed Posted November 20, 2012 Share Posted November 20, 2012 Issue gel AHG compatible units. Things can get sticky though if the anti M reacts when doing the immediate spin crossmatch. Link to comment Share on other sites More sharing options...
dld Posted November 21, 2012 Share Posted November 21, 2012 Prewarm technique in tubes, crossmatch compatible at AHG. If serum reacts at AHG using this technique, we would then have to find M-negative units. Link to comment Share on other sites More sharing options...
Eagle Eye Posted November 21, 2012 Share Posted November 21, 2012 AT our place...we see this a lot with our population (we do not run saline tube method), give gel crossmatch compatible blood.For pregnant patient we run tube screen (with LISS) and if reacting at 37/AHG, we do prewarm screen. If the prewarm screen comes out positive, our MD gives us guidance. Most cases MD wants to give gel crossmatch compatible. But if prewarm is reacting, we get heads up on what give it to baby.[QUOTE=SMILLER;49365]You have a gel screen/panel that shows a clear pattern for M showing dosage. You run it in 30 minute inc saline tube, all negative. The patient has no history of transfusion -- so apparently this is a naturally occuring anti-M, or possible a cold showing M reactivity.What next if one wants to crossmatch a couple of units?Thanks, Scott Link to comment Share on other sites More sharing options...
Rh-fan Posted November 22, 2012 Share Posted November 22, 2012 In the UK, we would give cross-match compatible blood (not typed to be M-) if the anti-M does not react strictly at 37oC, in line with Daniels G, Poole J, de Silva M, Callaghan T, MacLennan, S, Smith N. The clinical significance of blood group antibodies. Transfusion Medicine 2002; 12: 287-295.In the Netherlands we select M neg typed units when the anti M is reactive at 37oC (not strictly reactive but also reactive). So whenever the anti M is reactive (also) at 37oC we select M neg units. Based on the same publication (different interpretation).Peter Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 22, 2012 Share Posted November 22, 2012 In the Netherlands we select M neg typed units when the anti M is reactive at 37oC (not strictly reactive but also reactive). So whenever the anti M is reactive (also) at 37oC we select M neg units. Based on the same publication (different interpretation).PeterUnder these circumstances, we will issue "historically" M Negative units, if the hospitals so wish, but rarely currently tested M Negative blood (because we want to reserve our currently phenotyped blood for known clinically significant antibodies, such as anti-Fya, anti-Jka, etc). Link to comment Share on other sites More sharing options...
Rh-fan Posted November 22, 2012 Share Posted November 22, 2012 Our units are mostly 'historical' phenotyped. All donations are tested for ABO CcDEe and K (every donation). A selection of those that are D, c or e neg are then further tested for Fy, Jk, MNS (and some others). When a donation is typed neg on 2 donations, the typing is then printed on the label (every donation after that). So we don not retyp our donatiosn if they are typed twice.Peter Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 22, 2012 Share Posted November 22, 2012 Yes, we are moving towards that too Peter, but, at present, we are still stuck with typing each time. Link to comment Share on other sites More sharing options...
rravkin@aol.com Posted November 22, 2012 Share Posted November 22, 2012 Scott, just curious to know the strength of the reactons.You have a gel screen/panel that shows a clear pattern for M showing dosage. You run it in 30 minute inc saline tube, all negative. The patient has no history of transfusion -- so apparently this is a naturally occuring anti-M, or possible a cold showing M reactivity.What next if one wants to crossmatch a couple of units?Thanks, Scott Link to comment Share on other sites More sharing options...
SMILLER Posted November 28, 2012 Author Share Posted November 28, 2012 RRVery weak but match M -- even showing dosage like an M. Which happens with some nusiance colds.Scott Link to comment Share on other sites More sharing options...
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