Hi, I'll explain this the way I explain it to my students. Having the FyA antibody (anti-Fya) means that, at some time in the past you were exposed to the FyA antigen. Antigens are proteins that sit on the surface of your red blood cells. Everyone has them and everyones combination of proteins (antigens) are unique. Since you don't have the FyA antigen (you are negative for FyA), if you are exposed to the FyA antigen, your body will see it as foreign and produce antibodies against it. Hence, why you have anti-FyA. This is a defense mechanism, which is what gives us immunity to viruses, bacteria, etc. It is not and abnormal thing, we just have to be sure any blood you receive in the future is negative for the FyA antigen. hope that helped. James