Kimster

It is considered a drug because it has a NDC number just like IVIG, coag products all of which are plasma derivatives.

Grifols bought Novartis Diagnostic division do a google of Grifols-Novartis and all the information is there.

Although kedrion now owns the brand Rhogam they still only have one donor site, and kedrion is such a young plasma company the other two Grifols and CSL have been around for over 100 years each.

First and foremost how does one not remember having an amnio? Second those administering the RhIG should be giving these moms the patient ID card that all of the products on the market have within the product insert. Next for your ER docs that keep administering RhIG for bleeding they should discuss with the Chief of OB and the Blood Bank Medical Director the protocol set in place by ACOG for multiple bleeding episodes.

Actually they do this on women who are not sensitized before 28 weeks. If the baby is negative (40% of the time with an Rh positive dad) then they would not have to have either dose of RhIG antenatal or post partum. And this would be in instances where they know for sure who the father is (10%) of all births are not the stated father in the US. If you do a search of the internet of HDN a mother who is not knowledgeable about the high safety rate of plasma based products would be scared to death to have a RhIG injection let alone all the misinformation on vaccines. So there are moms that will pay for this test no matter what the OB says.

I heard about this company about 5 years ago, at that time only NY used the test. Myself and a few friends have encountered a few OB offices utilizing this testing, (not that often) it is still very expensive and not sure if the insurance companies are covering or out of pocket for those who are paranoid about blood based products. I know at one time it could not detect Rh in some blood types or something like that. http://laboratories.sequenom.com Hope everyone had a safe and great Memorial Day! K

I met this lovely gentleman at the CABB meeting after he had given one of his great presentations on Rh, I talked to him after the presentation was just knocked over by his patience for with my questions.

We actually got rid of the micro-dose because first it was ordered for patients that were not candidates for a mini dose. Second the price was almost the same as a full dose and why worry about the having two to stock. It is always better to give more than not enough, many OB patients due dates may be changed after the first trimester to an earlier date. Look at Ramsey et al in Arch of Pathology Lab Med, March 2009 regards to underdosing, I'd rather be safe than sorry.

Gee, I didn't think HyperRho even existed anymore. Always was considered the cheap Rhogam because it only had one viral removal step. Plasma products these days always have two or more. We use Rhophylac IM at 28 weeks and then IV post partum, mom's really like that

All RhIG products have a NDC number-rhogam, HyperRho, Winrho and Rhophylac.

John, I would look at any publications by Giancarlo Mari MD at University of TN, the doppler is his topic and also Ken Moise MD he really is the guru of HDFM.

Not sure if this would interest you, but there is concern on Rh negative pregnant women over 28BMI and absorption of RhIG by intramuscular administration. The Woefler study in Transfusion 2007 showed a dramatic drop in absorption after 3 days in these women. And as we know it takes up to 7 days for a preventive titer to be absorbed, this could put them at risk of sensitization. Just a thought.

ITP patients who are treated with RhIG typically have chills, fever, kind of a flu feeling post treatment. They usually are given tylenol and benadryl to counteract some of the symptoms. Once again RhIg is dosed by weight, something we do not generally take into consideration if more than one syringe is needed, I am talking about those rare occasions where perhaps 4 syringes are needed, that would be 1200 mcg of RhIG. Moms with new babies are not going to want to feel like they have the flu.

I realize the timing, I mean we do not think of total dose vs the weight of the patient and could she tolerate such a dose all at one time. Should they be spaced out over a period of time? I think we need to look at multiple dosing differently when giving IV, but not sure what we should do.