I just got inspected by JC and got hit on my Ortho panels. They recommended I do QC with a diluted anti-D on each panel to ensure the panel is working according to manufacturer recommendations. I've been looking into this for a bit now and I plan on making the the following change to my process. This process is the same for both my in date panel cells and expired cells.
Ultimately, the reason for all of this is to prove red cell viability. We all perform quality control on our screen cells; I use a QC kit. We then test a patient that happens to demonstrate one or multiple reactions on the detection phase. This patient sample is now used to QC our panel cells. We basically validated our patient with cells that were QC'd.
When running the patient (QC sample) against the panel cells, we will detect positive reactions, proving the viability of the cells. When doing additional rule outs, I will also select a cell that is positive for the suspected antibody, to ensure I also get a positive reaction there. Basically, every panel I use will have at least one positive reaction to prove red cell viability.
If no reactions are noted, I will have a troubleshoot guide (repeat testing, try a different panel, repeat AB screen, antigen type panel, etc...).
I plan on using this same process to prove red cell viability in expired red cells. I think this is safer than doing random QC for a limited number of antibodies, you are ensuring the reactions on the QC'd screen cells are reacting on the panel each time you have a positive antibodies vs. "Should periodically perform quality control on panel cells" as stated by the manufacturer.
As far as the disclaimer goes, I think I will wait for something more concrete for these inspectors. I am currently working on responding to JC with this process and see if they are in agreement.