We initially saw the Safe T Views center turning pink right out of the frige when applied to units. When I called the company they recommended we apply them while units are still in the frige. Since we tried that we haven't had issues. Perhaps if blood is set up ahead of time, kept in frige for some time, then the temp applicators are put on right prior to issue, you will see less issues. We use the 1-6, only for cooler issuance, and require units be started or returned within 4 hours of issue. Although our coolers maintain temp longer than that, we decided to keep it as 4 hours because everyone is used to our "transfuse within 4 hour of issue" policy. Our overall RBC wastage is less than 1%.