RichU

Hi Rich,

Yes you can, and, don't forget, under BSH Guidelines, you do not have to give blood that has been tested for the Cw antigen, if the unit is compatible by IAT with the patient's plasma/serum.  It is one of the few Rh antigens that can be given under these circumstances.

Be aware though, that I answer this in the knowledge that you are working in the Isle of Man (i.e. the UK).  This may not apply in other parts of the world (particularly Lithuania and Finland).

Serious Hazards Of Transfusion (SHOT) have haemolytic transfusion reactions in separate reporting categories.
All of the following can be 'Serious Adverse Reactions';
HTR Acute
HTR Delayed
HTR Hyperhaemolysis
FAHR
 
See SHOT definitions if you want more info.
SHOT Definitions - Serious Hazards of Transfusion

@Malcolm Needs, I have done as you suggested and await a reply.
Rich

Hi and thanks for your replies. Sorry for not updating - i've been off work.
Our enzyme method is papainised cells tested using BioRad NaCl cards.
A follow-up sample reacted exactly the same for us but the reference lab report a unspecified antibody by IAT and enzyme IAT, don't say they cannot exclude anti-D or anti-E and require no further samples this pregnancy.
 
Rich

Hi and thanks for your replies. Sorry for not updating - i've been off work.
Our enzyme method is papainised cells tested using BioRad NaCl cards.
A follow-up sample reacted exactly the same for us but the reference lab report a unspecified antibody by IAT and enzyme IAT, don't say they cannot exclude anti-D or anti-E and require no further samples this pregnancy.
 
Rich

Ah ok. Makes sense.
Cheers

How do you know a positive screen isn't caused by an alloantibody underlying the prophylactic anti-D unless you do an ABID?

Jsbneg,
 
Am I missing something. You said the patient was truly a type O after receiving several type A RBC's. Maybe I'm missing something in the message

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

The same phenomenon is seen if you use a spun sample for DATs.
The cells at the top can be negative and the ones from the bottom positive if recently transfused.

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

This statement is completely true, BUT the fact that NHSBT RCI Laboratories started to use these routine techniques followed a huge amount of work performed by Gordon Burgess when he was the Reference Service Manager at NHSBT-Cambridge Centre (before he became Head of RCI in NHSBT) to show that these were viable techniques that passed prolonged Quality Assessment.  To introduce such techniques without such work would not have allowed RCI to pass inspections by our various assessors.

I doubt if Clarest would be able to introduce such techniques into Canadian laboratories without similar work.

BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn states 'Anomalous or indeterminate cord Rh D groups should be treated as D positive until confirmatory testing is completed.'
For neonate transfusions see Malcolm's answer.
 

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I used this case study as part of my Higher Specialist Diploma in Blood Transfusion.
The IBMS have asked if I would like to give my PowerPoint presentation ('What the f?') at the 2023 Congress.
Thank you to all the contributors - I will certainly big up PathLabTalk if I do get to do it.
Rich

I guess low titre anti-A and anti-B.
We don't have any whole blood. The usual major haemorrhage pack provided is 4 red cells and 4 FFP for transfusion in 1:1 ratio.
During the TT motorcycle road racing we keep a box of 2 O neg red cells and 2 group A FFP for immediate use. This hopefully gives us time to test a sample and issue group specific if further units are required.