When a new lot is received a new lot verification of performance occurs. I must review all of these documents and sign them as reviewed. There is a comment stating that the technical supervisor's signature indicates that the package insert has been checked for updates / changes. This puts the "burden" on my shoulders, but this way I am assured that the t's are crossed and the i's dotted on this issue. When we receive a new lot of reagents, it is tagged with an orange sticker from a "dating" gun (sort of like the guns the supermarkets used in the past to place prices on items). This color indicated that the item has been received, but a new lot verification and QC need to be performed prior to the lot's use. Once the new lot verification has been performed, a blue sticker (3/4" Avery round stickers) is placed on all items in the lot indicating that the new lot verification has occurred. When the lot goes into use a green sticker (same as the blue stickers) is placed over the blue sticker on the entire lot and a date placed on each item as the bottle or rack of cards, etc is placed into use. This is the system we have used here for over 20 years and it works well for us. The lot changes are documented in the workbook as appropriate to allow tracking of reagent change down to the specific specimen a lot was started upon. The change of lot number is documented in red ink in the workbook to make it easier to find.