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Showing content with the highest reputation since 07/09/2020 in Posts

  1. 4 points
    and then give the rest of us a book report!
  2. 3 points
    I can't refresh your memory, but I do know of a case of anti-Vel in the UK that caused a fatal transfusion reaction. The DAT was positive by anti-complement only, and the anti-Vel itself could only be detected in a clotted sample, not in an EDTA sample.
  3. 2 points
    cswickard

    Donor re-typing

    I was also thinking about 'why not drop the unit retesting' after all of the donor centers went to computerized donor labeling/retesting and I hadn't seen a labeling error in years (you did use to see a very few go by) and then realized that with so many places going to computerized "compatible unit release" - the retesting done by the receiving facility is the only chance they get to check that the RBCs in the unit do indeed match the label on the bag. Without, at least, an Immediate Spin crossmatch check of the unit vs. the pt - there would be NO other physical check done if unit retesting was dropped. So there we go, the inspection agencies will want the unit recheck for forever! If the UK's figures were studied and accepted by the FDA/CMS/AABB, etc. - we might eventually see a change, but it probably won't be soon. (my 2 cents )
  4. 2 points
    "Compatible blood for a corpse is not a triumph" (sorry - forgot who to attribute this to)
  5. 1 point
    I may be old school but if I don't have the antisera I'm getting ag negative rbcs from my supplier. Though anti-M that is not clinically significant works for me. Otherwise I cannot think of one.
  6. 1 point
    There are quite a few (too many to mention here). Can I cite for you, NHSBT Guidelines in your search engine, followed by looking for SPN214/3 (SPN stands for specification) and up will pop a document entitled "The Clinical Significance of Blood Group Alloantibodies and the Supply of Blood for Transfusion., written by my very good friend Nicole Thornton, Head of Red Cell Reference at the International Blood Group Reference Laboratory in Filton (Bristol) in the UK. If I tell you that the document is 22 pages long, you may understand my first sentence!
  7. 1 point
    Joanne P. Scannell

    Flying Squad Blood

    Without some sort of 'vending machine' device to control and document the in/out/in/out/transfused to whom information, just leaving O Neg RBCs in a refrigerator somewhere for nursing to take/return at will is not a good idea. I'm not even sure if regulatory agencies will support that. Not only that, giving O Neg to 'everyone' is not good management of resources. We (and most hospitals in our area at) restrict the use of O Neg to Females <50yrs old. (And even that is coming up for debate in some arenas.) There are 'vending machines' out there that will interface with some Blood Bank Software. Maybe someone who is using such a machine can comment on that.
  8. 1 point
    srichar3

    Flying Squad Blood

    O Neg that is kept in a fridge that nurses/doctors can take in urgent situation without been crossmatched or issued to a patient.
  9. 1 point
    Good luck with your course if you don't read around the subject. I am certain you will pass with flying colours.
  10. 1 point
    Yes, you are completely right Malcolm and others. My experience is limited to common positive DAT results for OB patients, which is the ABO mismatch. Those positives are usually 1+ or weaker. That's why we always do a microscopic if we get a macroscopic negative. I forgot that Rh mismatch DATs can go from 2+ to 4+ positive, because I hardly ever come across those. Thank you.
  11. 1 point
    HN327

    COMPLEMENT POS DAT AND FULL CROSSMATCH

    For our procedure, we would perform a Cold Antibody Screen. If it is panreactive, then the patient is suspect to have a Cold Auto Antibody. We would only give electronic crossmatch. If it is selectively reactive, we would perform a cold panel to identify the cold antibody and give antigen negative for the clinically significant antibody. We used to do immediate spin crossmatch a few years back but it almost always positive due to the cold auto, which would reflex to full crossmatch. Our medical director changed the process.
  12. 1 point
    I have cited this reference over and over and over again. Sachs UJH, Röder L, Santoso S, Bein G. Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases. British Journal of Haematology 2006; 132: 651-661, and it refers to transfusion reactions too.
  13. 1 point
    Sorry, you must be fed up with me. I know I am like a dog with a bone, but, although IgG is a monomer antibody, it does have a valency of two, which is why, occasionally, it can cause agglutination visible to the naked eye. Notably, some examples of IgG anti-D cause agglutination at 37oC with D--/D-- red cells, with no potentiator.
  14. 1 point
    TriciaHu

    Epic and blood bank

    Our blood bank (~900 beds) went live with HCLL and Epic in August 2019. There have been a lot of bumps along the way. We previously had Cerner and wish we could go back. We were told that HCLL was the best BB system to use with Epic, but we think Cerner was probably better. Every day we have to correct something that is just an HCLL-ism. The system has caused extra work for our techs and management alike. With all that said, I think it would work really well for a much smaller blood bank that doesn't do traumas as much.
  15. 1 point
    applejw

    Donor re-typing

    The requirement to perform a donor retype also plays into whether or not the LIS is used for electronic compatibility testing. AABB 5.16.2.4 The system contains logic to alert the user to discrepancies between the donor ABO group and Rh type on the unit label and those determined by blood group confirmatory tests and to ABO incompatibility between the recipient and the donor unit. * *FDA Guidance for Industry: Computer Crossmatch"
  16. 1 point
    I am a worker from/in the UK, but if TRM.40780 says, "Maternal RhIG candidacy assessment must include the identification of weak-D phenotype newborns", that is exactly what it means. It doesn't say "should" instead of "must", and it doesn't say, "until you give up because you are bored, because you have never found one"! Yes, such types are rare, but they do happen, and they can cause the mother to produce an anti-D (of sorts). These antibodies are not usually particularly clinically significant in terms of further pregnancies - but the word "usually" is the important one in that sentence. The only thing I would say is, WHEN you do detect a newborn who tests as weak-D positive, don't forget to test the mother too; she may also express the same weak-D type (but, depending upon your laboratory's policy, may not have been tested as expressing this type during the pregnancy), and, if she does, she doesn't need the anti-D immunoglobulin (which, remember, is a human-derived blood product, which may contain a novel blood-borne virus type about which we know nothing - YET).
  17. 0 points
    I have never heard of your references. The main texts for my course includes AABB technical manual by Fung, Harmening's Modern blood banking and transfusion services, and AABB's Standards for blood banking. I am only a part time SBB student, I work full time as a Medical Technologist. This is my final semester. You don't need to show me references I never heard of, I am certain you are right. Mom's with PARTIAL D (NOT WEAK D, WE DON'T TEST WEAK D FOR MOMS) can be typed as Rh positive, but still may form Anti-D when exposed to Rh positive red cells from baby(Modern Blood banking and transfusion services, Harmening, 7th Ed. p. 160).
  18. 0 points
    We do weak D testing on all cords bloods that test negative with Anti-D. Regardless if the mom is Rh positive or negative.
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