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Showing content with the highest reputation on 11/17/2017 in all areas

  1. wAIHA with IgM and C3c/C3d coating

    AMcCord reacted to Malcolm Needs for a post in a topic

    1 point
    I agree 100% with you that anti-Vel can be a real problem, but that problem can be a real problem not just when the antibody is new. It is one of the few antibodies that are best detected by the two-stage indirect antiglobulin technique (see Geoff Daniels' book, Human Blood Groups), but I don't know of anyone in the world who uses that technique as a routine. The reason that this is the best technique to use for anti-Vel is that it is much more easily detected with anti-C3d than either anti-IgM or anti-IgG, however, of course, in these days of automation, most people use samples that have been anti-coagulated with EDTA. This means that the calcium, magnesium and manganese ions required as co-factors in the initiation of the classical complement pathway are not available, and so we no longer see the tell-tale haemolysis in our tests that is normally seen with an anti-Vel (and, of course with ABO antibodies, some anti-I antibodies from an adult i individual, anti-P+Pk+P1 from a p individual, and IgG anti-Lea). Indeed, I think I have noted on Pathlabtalk before that I know of one case of anti-Vel that proved to be fatal, which was only ever detected in a clotted sample from the patient, but NEVER in an EDTA sample.
  2. wAIHA with IgM and C3c/C3d coating

    BankerGirl reacted to SMILLER for a post in a topic

    1 point
    Vel, as always, I appreciate your response, Malcolm. Scott
  3. I just answered this question. My Score PASS
  4. 1 point
    I just answered this question. My Score PASS
  5. BloodBankTalk: Allergic Reaction

    Malcolm Needs reacted to DPruden for a post in a topic

    1 point
    I just answered this question. My Score PASS
  6. Lewis A

    StevenB reacted to Malcolm Needs for a post in a topic

    1 point
    Sorry Scott. In my personal opinion, and it is only my personal opinion, it's not 20th century........it is at best 18th century!!!!!!!!
  7. 1 point
    Absolutely the advice given to you was correct. For a start off, as you say yourself, 80% of A2B individuals do NOT make an anti-A1, but of those 20% who DO make an anti-A1, how many will make that anti-A1 as a result of immunisation as a result of transfusion or pregnancy? The answer to that, if you read any book concerning blood group serology (and that is NOT a criticism of you - we all started somewhere, including the very best, such as Herr Dr Willy Flegel, and others - and I have HUGE respect for Willy), you will see that a clinically significant anti-A1 is amazingly rare. For an anti-A1 to be clinically significant, it has to react strictly at 37oC, and that is a VERY rare "animal", and no example of anti-A1 has EVER been implicated in a case of HDFN, so, PLEASE, do not worry about giving A1B (or even A1) blood to an A2B individual, even if they have an anti-A1 in their circulation, UNLESS they have an anti-A1 that is actually active at strictly 37oC.
  8. BYOB, I suggest.
  9. Why we do not have Micro in the Blood Bank

    bldbnkr reacted to aafrin for a post in a topic

    0 points
    Even docs don't understand BB. We had a pediatric registrar who was insisting on issue of O Rh negative FFP to a 3 yr old baby with B Positive blood group who had suddenly started bleeding at night and we didn't have any B group FFP in stock. He was refusing to accept AB group FFP which the tech had thawed. I had to step in & talk to consultant at 2 am & convince him for them to accept AB Group FFP.

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