We had a LOT of problems with the TempStrip 10 indicators last summer. I personally experienced the monitor changing to the blue color even on an iced unit, within about 10 minutes. I contacted the company, and they explained the process to me...which kind of made sense. Basically the liquid needs to be chilled to keep it from migrating into the white window, as soon as the indicator is activated. We've adjusted the way we activate and store the monitors and haven't had any problems since.
I can't really explain why the pre-activation and cold pack storage works better than just sticking them onto a prechilled unit of blood and then putting it directly between ice packs...but it does.
Here's part of the summary that I put together, for our staff to use in preparing the indicators:
"Although the package states that no conditioning is needed…special handling is required at the time of activation, so that the breach window will not turn blue even when blood units are stored appropriately.
BT10 strips contain an encapsulated blue liquid. The indicator is activated by squeezing the bubble to release the blue liquid. The blue liquid changes the yellow activation window to green. The activated BT10 must then be cooled to 6° C or colder, in order to prevent the blue liquid from migrating into the white breach window.
Immediately after activating several BT10 stickers, place them in the blood bank refrigerator, on top of a chilled “cold pack.” (Don’t peel the paper backing off until applying it to a unit of blood.)"