Posted July 10, 20168 yr comment_66459 Just a question regarding ce (f) ag when dealing with warm autos. If the patient phenotypes as R1R2 is it prudent to provide c neg rbcs or just go with Rh ag specific? I have always gone with ag specific but I find the reference lab used by my current assignment recommends "c" neg. Looking for opinions please. Thanks in advance.
July 10, 20168 yr comment_66461 I would go with you David; if it is an auto-antibody, it is a mimicking specificity in the first place (and so not actually anti-f), and, secondly, the transfused rec cells will last as long as autologous red cells anyway.
July 11, 20168 yr Author comment_66464 Thanks Malcolm. The reference lab is recommending c neg so that anti-f is not formed. There is no specificity to the autoab.
July 11, 20168 yr comment_66465 Oh I see; sorry. Well, if we have a patient who has made an anti-f (usually an R1R2), we usually say give either R1R1 or R2R2, but, if the patient has an auto-antibody and has not got anti-f, we would recommend just Rh antigen specific, and by that, I mean you could give an R1R2 patient virtually anything in the way of Rh, so I still go with what you say!!!
July 12, 20168 yr comment_66483 We give our R1R2 patients with warm autoantibody whether the warm auto is currently detected or historical with little c or little e negative RBCs whichever is available. Little c negative of course is much easier to find than e.
July 12, 20168 yr Author comment_66485 11 hours ago, WisKnow said: We give our R1R2 patients with warm autoantibody whether the warm auto is currently detected or historical with little c or little e negative RBCs whichever is available. Little c negative of course is much easier to find than e. thanks
July 13, 20168 yr comment_66494 We don't worry about the f unless the patient has a true anti-f. Seems kinda overkill to me, but that's just my opinion.
Create an account or sign in to comment