B Postive Posted September 27, 2013 Share Posted September 27, 2013 Does anyone know if the granulocytes need to be negative for any allo-antibodies that the patient may have? I understand that they have to be ABO/Rh compatible. I cannot seem to find anything related to my question. Link to comment Share on other sites More sharing options...
David Saikin Posted September 27, 2013 Share Posted September 27, 2013 I haven't used them in years. As I recall they were rather bloody so I would think that would be prudent but I can't say for sure if it is a requirement. Don't recall it being one. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted September 30, 2013 Share Posted September 30, 2013 Cartainly, way back, when I was working in hospitals (and Noah was building his Ark), we always used to cross-match these because, as David says, they contained a lot of red cells. Given that these tend only to be transfused in extremis, when the patient is already very ill, the last thing they would want is a transfusion reaction to add to their woes. Link to comment Share on other sites More sharing options...
aafrin Posted October 2, 2013 Share Posted October 2, 2013 I agree with David & Malcolm. We had a clinical trial going on with end stage ca patients with multiple mets. They were to be transfused with granulocyte concentrates (GCs) according to the trial protocol, but cross matching of GCs was not included in it. When the actual unit was sent for transfusion, the ICU doctors saw the GCs contained a lot of red cells. So they referred the blood bank and we went & saw the guidelines for GC on net and recommended cross-matching. The same was incorporated in the protocol. Link to comment Share on other sites More sharing options...
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