C3d Positive DAT in cord blood.

[Liz]

Retire!!?? what!! why?

At what age should one retire??

[Malcolm Needs ☆]

I vow to retire when I stop enjoying my work (which, at present, I still love), or when I become so old and decrepit that my mind no longer can keep up with things (certainly on the horizon and getting closer)!!!!!!

Until then, they're just going to have to put up with me.

[bbbirder]

We recently had an infant born to a mother with ant-Jka. DAT on the cord blood was positive, IgG only, no C3 (I tested it because of reading Malcolm's postings.)

The interesting thing to me was that while the Jka was 4+ in the Mom's plasma on the Echo (Solid phase), the cord serum was negative in gel and tube. Eluate from the cord cells showed the Jka antibody, 2-3+ in gel. We tested the cord serum on the Echo (we normally don't put those sticky cord bloods on our analyzer) and the anti-Jka reactions were 2-3+.

The baby had a bili of 7.5 when discharged at 2 days. Follow-up through physicians office, so I don't know if it went higher or not.

While Kidd HDFN is usually mild, wasn't the antibody first discovered because of HDN?

[Malcolm Needs ☆]

Absolutely spot on bbbirder. The lady also had an anti-K, but this could not have caused the HDN, because the baby was K-.

Allen FH, Diamond LK, Niedziela B. A new blood-group antigen. Nature, Lond., 1951; 167: 482.