ChrisH Posted August 15, 2011 Share Posted August 15, 2011 They can not delevope anti-Fyb correct? or am I wrong? Link to comment Share on other sites More sharing options...
David Saikin Posted August 15, 2011 Share Posted August 15, 2011 If they are antigen negative then they should be able to make the corresponding antibody. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted August 15, 2011 Share Posted August 15, 2011 It depends on whether or not they are homozygous for the GATA-1 mutation gene.If they have this mutation, then, very often, although not always, they carry the FYB gene, but, because of the mutation, the Fy( antigen is not expressed (specifically) on the red cells, but is expressed on other tissues. Therefore, the immune system does not recognise the Fy( antigen as foreign.If they have this mutation, but DO NOT have the FYB gene, or if they DO NOT have the mutation and are genuinely Fy(a-b-), then David is absolutely correct, and they can make anti-Fyb (although they are far more likely to make anti-Fy3 in that case)! Link to comment Share on other sites More sharing options...
ChrisH Posted August 15, 2011 Author Share Posted August 15, 2011 Thank you Malcolm and David. Link to comment Share on other sites More sharing options...
Ajac Posted August 15, 2011 Share Posted August 15, 2011 There's a good review on Duffy in this issue.IMMUNOHEMATOLOGY, Volume 26, Number 2, 2010 Link to comment Share on other sites More sharing options...
ChrisH Posted August 15, 2011 Author Share Posted August 15, 2011 Ajac, very good reading. Link to comment Share on other sites More sharing options...
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