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Sickle cell transfusion


pbaker

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Usually the only reason we know they have sickle cell disease is because of their diagnosis, sickle cell crisis. We put them on sickle cell neg protocol and always give sickle neg. cells. If they have the trait we would never know.

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prepare blood which is sickle negative .

usually in our blood bank we use to do also full phenotyping for these patient in the 1st visit and prapare blood for them which is Rh & K Negative with the patient phenotype, for example if the patient phenotype is ( e +, E -, c + , C + , K-), blood which is E-, K-, will be prepared for him.

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Only to Sickle Cell Disease. We also provide Rh (complete) and K matched RBCs if the patient has no history of clinically significant antibodies; and complete phenotypically matched if they do have any history of antibodies.

Like you, we do not see a lot of these patients in my current Institution. Because of this, I have found that even Physicians admitting those patients here do not always know that standard of practice (I have worked other places that do service a lot of Sickle Cell patients). So they may not even request any of these attributes; in which case, we call and "educate them" so they can modify the Order to reflect our practice.

Brenda Hutson

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We give sickle neg blood to those with the actual disease state. We wouldn't know about the trait anyway. While we do not have a large adult sickle population we do have a large pediatric population and I once asked the pedi hem/onc sickle specialist

about it. We had given a kid blood to a sickle kid without its being tested ( because we didn't know the diagnosis) and just filled the orderas written. She said the main reason was so that as they follow these patients on chronic transfusion therapy with hemoglobin electrophoresis they would get accurate HGBS results and not from a unit which had the trait. It wouldn't hurt them. We also provide c,E and Kell matched if there are no antibodies and fully phenotyped matched if there are antibodies.

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Just a comment regarding your last sentence (and perhaps it is just how I am interpretting it). That is your statement that you give c,E,K matched blood. Not sure if you mean "Rh system" (i.e. DCcEe matched) ; or if you were specifically saying c,E,K only? The reason I say that is due to a scenario we had here once; again, due to Physicians here not having much experience with SS patients and maybe having read "just enough" to throw around some terminology when it may not be accurate. While the most common phenoytpe of these patients is going to be Ro, that certainly is not always the case. So we had a Physician Order C-E-K- RBCs (and for that matter, the patient could also be K+). I had to explain to him that we would never make an assumption of the type; that we will need to type them first but that we will match them to their type.

Brenda Hutson

We give sickle neg blood to those with the actual disease state. We wouldn't know about the trait anyway. While we do not have a large adult sickle population we do have a large pediatric population and I once asked the pedi hem/onc sickle specialist

about it. We had given a kid blood to a sickle kid without its being tested ( because we didn't know the diagnosis) and just filled the orderas written. She said the main reason was so that as they follow these patients on chronic transfusion therapy with hemoglobin electrophoresis they would get accurate HGBS results and not from a unit which had the trait. It wouldn't hurt them. We also provide c,E and Kell matched if there are no antibodies and fully phenotyped matched if there are antibodies.

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