Anti-CD36 (anti-GPIV) Frequently Interferes With Routine Red Blood Cell Antibody Testing in Patients of African Descent-References?

[Mabel Adams]

"Anti-CD36 (anti-GPIV) Frequently Interferes with Routine Red Blood Cell Antibody Testing in Patients of African Descent" is a plenary session at AABB this fall.  I can't find any useful information on it through an internet search.  Does anyone have any references or information on this, which I assume will be a therapy at some point.

[AMcCord]

I didn't find much either, but from what I did find it looks like it could be another interesting blood banker's problem since CD36 is definitely found on RBCs. And it sure looks like it may be utilized with immunotherapy for multiple kinds of cancer treatment to make it more effective. Or for FNAIT.

https://pubmed.ncbi.nlm.nih.gov/1382721/

The link below is interesting - not sure how it would relate. 

https://pubmed.ncbi.nlm.nih.gov/8623134/

And then there are these tidbits:

https://pubmed.ncbi.nlm.nih.gov/34041523/

https://www.ahajournals.org/doi/full/10.1161/01.atv.16.7.883

If patients with African descent are more likely to develop anti-CD36 due to CD36 deficiency, are their red cell ABO types (or other antigen types) going to be affected by that antibody (which would be an autoantibody)??? 

I'm with Mabel - anyone out there know anything about using anti-CD36 for cancer treatment or FNAIT treatment?

[snance]

Some references related to the Platelet Glycoprotein, GPIV

B. R. Curtis, J. G. McFarland. Human platelet antigens – 2013. Vox Sang 2013;106:93-102

Curtis BR, Ali S, Glazier AM, et al.: Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion 2002; 42: 1173–1179

Ikeda H, Mitani T, Ohnuma M, et al.: A new platelet-specific antigen, Naka, involved in the refractoriness of HLA-matched platelet transfusion. Vox Sang 1989; 57: 213–217

Curtis B, McFarland J: Detection and identification of platelet antibodies and antigens in the clinical laboratory. Immunohematol 2009; 25: 125–135

[AMcCord]

19 hours ago, snance said:

Some references related to the Platelet Glycoprotein, GPIV

B. R. Curtis, J. G. McFarland. Human platelet antigens – 2013. Vox Sang 2013;106:93-102

Curtis BR, Ali S, Glazier AM, et al.: Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion 2002; 42: 1173–1179

Ikeda H, Mitani T, Ohnuma M, et al.: A new platelet-specific antigen, Naka, involved in the refractoriness of HLA-matched platelet transfusion. Vox Sang 1989; 57: 213–217

Curtis B, McFarland J: Detection and identification of platelet antibodies and antigens in the clinical laboratory. Immunohematol 2009; 25: 125–135

Thank you!