Hello again, What is the frequency of the C, E antigens on D negative red blood cells? We have a male patient who received O Positive uncrossmatched emergency units in 2011. Now he is showing an Anti-D antibody. The tech who performed the crossmatches yesterday did only an immediate spin with an O Negative donor unit without ruling out Anti-C or Anti-E because the panocell results looked like Anti-D. The units were issued early this morning before a QA could be performed. I phenotyped the patient's initial T&S cells obtained before he received packed cells. Patient is type O Rh D=, C=, E= . What would be the probability of this patient forming either Anti-C and/or Anti-E as well? My ARC reference lab pathologist is on vacation, but I sent her an email asking this. Unfortunately, the patient is inhouse and symptomatic. Any help would be appreciated since I am new to BB mommahood.