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  1. Malcolm Needs

    Malcolm Needs

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  2. Cliff

    Cliff

    The Help


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    goodchild

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  4. Bb_in_the_rain

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Showing content with the highest reputation on 07/13/2018 in all areas

  1. Folks, please read this carefully, I suggest he is saying it is acceptable to call him Malcolm, as compared to Mr. Needs - hence informal. He did not suggest he would find it acceptable to refer to him as a tosser, wanker, or some other (really cool sounding British) pejorative. I need to move to England, if only for a short time. American English is so boring.
    2 points
  2. Whats boring is American quality control departments? Cannot do anything without running into red tapes. :~
    1 point
  3. Malcolm Needs

    IgG or IgM?

    Well dothandar, the answer to your first question is "YES", because this phenomenon has been seen many times over many years. In those earlier years, experiments were performed to determine the immunoglobulin molecules present, and in every case there was a mixture of IgM and IgG. In the end, it was decided that performing such experiments was a waste of time and money, for very little return. Why reinvent the wheel now? Turning to question two, all immune antibodies start off as IgM as a result of primary sensitisation, but then quickly change to IgG, even from the primary sensitisation (and almost always from a secondary sensitisation), and, undoubtedly, some IgG antibodies can cause agglutination when no potentiating agents are present (for example, IgG ABO antibodies), however, this is not true of Rh antibodies. In the case of Rh antibodies, it is not a function of the antibody, so much as a function of the number and proximity of the antigens. This can be seen with certain examples of human-derived IgG anti-D, which never cause "saline agglutination" at 37oC with red cells of "normal" Rh types, but do so with red cells exhibiting the exulted-D types (such as D--/D--, DCw-/DCw-. etc, because the number of D antigen sites available, particularly towards the outer layer of the sialic acid cloud, allow for Rh IgG immunoglobulins to come close enough between two (or more) different red cells to cause agglutination. However, even in such a situation, the incubation temperature needs to be 37oC, and not "room/ambient" temperature.
    1 point
  4. I have heard of this kind of thing once before in 43 years of working (it was in Scotland), but, SORRY, I don't think anyone ever got to the bottom of the cause. I realise that doesn't help much!
    1 point
  5. I think the term "Chav" has recently become popular. Even more recently, calling someone "a right old Neymar" is not very flattering. As the Irish writer George Bernard Shaw once said: "England and America are two countries divided by a common language."
    1 point
  6. You can never charge two HCPCs codes for a single transfusion. You also can't individually charge testing/processing CPT codes if there's a bundled HCPCs code that describes it best.
    1 point
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