Posted February 11, 201510 yr comment_59244 Does someone know of a link to a one or two-page Antigen Chart? You know, one that lists antigens, thier reaction characteristics, and how common they are? We have a big chart, but it would be nice to have a smaller one that we can stick up in our student cubby, so when we ask inpertinent questions like "how many units are you going to have to screen in order to get two compatable...", they can do the math. Thanks Scott
February 12, 201510 yr comment_59257 Found it!Anti-f may mimic Anti D+C with C showing higher dosage – can cause DHTR and HDN Please check the note at bottom..........Isn't anti-f is combination of anti-c+e?
February 12, 201510 yr comment_59260 You are perfectly correct in one way Eagle Eye, except that anti-f is not a combination of anti-c+e, but a compound anti-ce - in other words, it will react with a ce antigen on the same haplotype (such as dce or Dce), i.e. when, for want of a better way of putting it, the RHc and RHe genes are in the cis position, but will not react with red cells when the c and e antigens are derived from different haplotypes (such as DCe/DcE), i.e. when, for want of a better way of putting it, the RHc and RHe genes are in the trans position. All that having been said, however,it is a typographical error anyway, as it should read, "anti-G may mimic anti-C+D, with the anti-C normally showing stronger reactions than the anti-D." Unfortunately, although citing an NHSBT Document at the bottom (SPN/DDR/RC/020/02), this is not from the actual document (which is 33 pages in length, which has just been updated by the author - Dr. Geoff Daniels on 12 January 2015 - and which does not contain this table).
February 12, 201510 yr comment_59264 You are both right - it was a typo sorry Double typo I had added it after a patient had a DHTR due to anti-f in flying squad units. Edited February 12, 201510 yr by Auntie-D
February 12, 201510 yr comment_59267 Auntie, that's a nice chart. One question: at the bottom of the red Antibody column on the left, below anti-Lub, there's an entry "Active @37oC" What is this refering to? Undetermined antibodies to low incidence antigens? Thanks - Phil
February 12, 201510 yr comment_59269 Auntie, that's a nice chart. One question: at the bottom of the red Antibody column on the left, below anti-Lub, there's an entry "Active @37oC" What is this refering to? Undetermined antibodies to low incidence antigens? Thanks - Phil Yup, but there wasn't enough room
February 12, 201510 yr comment_59270 Also curious about the frequency column, assuming this is the freq. of compatilbe units, I think k(cellano) and Kpb frequencies are in error. The frequency listed for these 2 antibodies reflects the "incompatible" rates.
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