BBNC17 Posted April 11, 2018 Share Posted April 11, 2018 We had an Rh positive donor tested at another facility as D+ C- E- c- e- . Typings were confirmed at our facility. Don't have any demographics on the donor yet, but how common (or uncommon) is this? Link to comment Share on other sites More sharing options...
Malcolm Needs ★ Posted April 11, 2018 Share Posted April 11, 2018 The D--/D-- or D../D.. phenotypes (the two are almost synonymous, but the D--/D-- type is negative for the Evans antigen, whereas the D../D.. type is positive for the Evans antigen) are both EXTREMELY RARE. Unfortunately, these individuals have a nasty habit of producing anti-Rh17 (essentially, an antibody directed against the C, c, E and e antigens), and can only safely be transfused with units that are themselves D--/D--, D--/D.. or D../D.., and if these are not available, units of Rhnull blood. An exciting find, but I wish you luck! John C. Staley and BBNC17 1 1 Link to comment Share on other sites More sharing options...
Marilyn Plett Posted April 11, 2018 Share Posted April 11, 2018 Please discuss the importance of donation with this donor, and register the donor with the American Rare Donor Program. I remember having a pregnant patient with anti-Rh17. I believe there were only a couple of units available nationally. If I remember correctly, we had to resort to autologous donation, iron, and EPO. Eagle Eye, BBNC17 and Malcolm Needs 2 1 Link to comment Share on other sites More sharing options...
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