Posted April 11, 20187 yr comment_73068 We had an Rh positive donor tested at another facility as D+ C- E- c- e- . Typings were confirmed at our facility. Don't have any demographics on the donor yet, but how common (or uncommon) is this?
April 11, 20187 yr comment_73069 The D--/D-- or D../D.. phenotypes (the two are almost synonymous, but the D--/D-- type is negative for the Evans antigen, whereas the D../D.. type is positive for the Evans antigen) are both EXTREMELY RARE. Unfortunately, these individuals have a nasty habit of producing anti-Rh17 (essentially, an antibody directed against the C, c, E and e antigens), and can only safely be transfused with units that are themselves D--/D--, D--/D.. or D../D.., and if these are not available, units of Rhnull blood. An exciting find, but I wish you luck!
April 11, 20187 yr comment_73071 Please discuss the importance of donation with this donor, and register the donor with the American Rare Donor Program. I remember having a pregnant patient with anti-Rh17. I believe there were only a couple of units available nationally. If I remember correctly, we had to resort to autologous donation, iron, and EPO.
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