Auto Anti-c

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Edited June 3, 2015 by RollSlow10

[Malcolm Needs ☆]

It most certainly is, and is an unjustified use of r'r' red cells.

 

The auto-antibody may well look like an anti-c, but is almost certainly a mimicking antibody that is reacting preferentially with c+ red cells.  The actual specificity is probably an antibody within the Rh Blood Group System, but is probably against a high prevalence antigen that is also present on r'r' red cells.  Therefore, giving r'r' red cells is a waste of time (and r'r' red cells).  The only time that r'r' red cells would be justified would be if the c+ red cells did not result in a rise in Hb and the Hb was at a dangerously low level.

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Edited June 3, 2015 by RollSlow10

[Malcolm Needs ☆]

So do I!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

 

Hopefully, the Pathologist in Charge of the supplier will talk your Pathologist out of the order.

[Marilyn Plett]

If you are in the USA, the mention of money can sometimes bring doctors off the ledge and back into reality. Rare units will be enormously expensive.

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Edited June 3, 2015 by RollSlow10

[David Saikin]

Maybe the pt's cells haven't absorbed to their fullest extent so it hasn't "spilled" into the plasma at this point in time - - -  it will come eventually (maybe)!  How's that for a hedge?

 

I always give Rh phenotype specific rbcs - these folks seem primed to make abs.  Whenever I ignore my rule on this invariably I am dealing with an Rh sensitization the next time I see the pt.  Not a scenario you want to get into with an active autoimmune.  Listen to Malcolm on this.  Whatever you infuse is going to be treated just like the pt's own cells so . . . good luck and enjoy.

 

PS - try setting up tubes using PeG, Incubate at 37C, wash 2x with diluent and make into 0.8% cells (if one drop of cells used, add 2-3 drops diluent to dry button) then spin them in an anti-IgG card.

Edited October 9, 2014 by David Saikin