Lulu Posted October 2, 2014 Share Posted October 2, 2014 I can't find the reason we use Anti-D series 4 and 5 on the Echo? Why not just one? I understand they are different clones but that seems to be all I understand Link to comment Share on other sites More sharing options...
Auntie-D Posted October 2, 2014 Share Posted October 2, 2014 Surely two clones is enough reason? As far as I am aware the second clone allows you to identify Du-s. There are two clones of A as well between full and confirmatory cards with some technologies. Lulu 1 Link to comment Share on other sites More sharing options...
goodchild Posted October 2, 2014 Share Posted October 2, 2014 There are a number of great articles discussing this topic. I'll post references later if someone else hasn't already done so. L106 and Lulu 2 Link to comment Share on other sites More sharing options...
kate murphy Posted October 2, 2014 Share Posted October 2, 2014 They detect different epitopes of the D antigen. Some D IV and D mosiacs may make anti-D if they are mistakenly typed as D Pos and transfused D pos. Or not get RHIG post partum. I'm looking for a reference for you. L106 and Lulu 2 Link to comment Share on other sites More sharing options...
Lulu Posted October 4, 2014 Author Share Posted October 4, 2014 Thanks for your response. I would appreciate the references if you all have them available. Link to comment Share on other sites More sharing options...
Sandy L Posted October 4, 2014 Share Posted October 4, 2014 If you have access to Transfusion journal, John Judd published an article comparing different anti-D reagents including which reagents will react with which partial D. Sorry I don't have it at my fingertips. Lulu 1 Link to comment Share on other sites More sharing options...
Eagle Eye Posted January 17, 2015 Share Posted January 17, 2015 Is there a chart somewhere which we can use to interpret RH results from Echo?how to interpret RH with following results...Echo gave interpretation for first three ...Eg. anti-D1 1+ and anti-D2 neg anti-D1 2+ and anti-D2 1+ anti-D1 0* and anti-D2 0 anti-D1 C and anti-D2 C---in this case ABO RH type gave C for all wells... Thank you in advance.... Link to comment Share on other sites More sharing options...
David Saikin Posted January 20, 2015 Share Posted January 20, 2015 Your package insert should explain the differences between those reagents. Link to comment Share on other sites More sharing options...
goodchild Posted January 20, 2015 Share Posted January 20, 2015 Thanks for reminding me that I was going to post some references. Here are just a couple articles I've compiled talking about Rh stuff.Denomme GA, Wagner FF, Fernandes BJ, et al. Partial D, weak D types, and novel RHD alleles among 33 864 multiethnic patients: implications for anti-D alloimmunization and prevention. Transfusion 2005; 45:1554–1560.Flegel WA, Denomme GA, Yazer MH. On the complexity of D antigen typing: a handy decision tree in the age of molecular blood group diagnostics. J Obstet Gynaecol Can. 2007;29:746-52.Flegel WA. How I manage donors and patients with a weak D phenotype. Curr Opin Hematol 2006;13:476–483Flegel WA. Molecular genetics and clinical applications for RH. Transfusion and Apheresis Science 2011;44:81–91.Sandler SG, Li W, Langeberg AL, Landy HJ. New Laboratory Procedures and Rh Blood Type Changes in a Pregnant Woman. Obstet Gynecol 2012;119:426–8.Denomme GA, Dake LR, Vilensky D, Ramyar L, Judd WJ. Rh discrepancies caused by variable reactivity of partial and weak D types with different serologic techniques. Transfusion 2008; 48:473–478 Link to comment Share on other sites More sharing options...
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