nick7791 Posted August 4, 2014 Share Posted August 4, 2014 i would appreciate your ans and feedback so i can understand and clarify Q1 patient 16 week pregnant has anti Bga, what should the tech dois it titration or include cell in the panel or something else Q2 D- C+ E+ c+e what are possible genotypesis it RGr' or r'r'' or Link to comment Share on other sites More sharing options...
AMcCord Posted August 4, 2014 Share Posted August 4, 2014 Anti-Bga is not considered clinically significant. I wouldn't do anything with it. Maureen 1 Link to comment Share on other sites More sharing options...
galvania Posted August 4, 2014 Share Posted August 4, 2014 And as for your possible genotypes, I would want to see the results of real molecular testing. This phenotype is just much too rare (it does exist) but it screams out that there's something funny. But just on the basis of what you've got - on both sides, a C on one side and a c on the other , and ditto for the E/e. So the following possibilities exist:dCE/dce or ryrdCe/dcE or r'r''Anna Link to comment Share on other sites More sharing options...
galvania Posted August 4, 2014 Share Posted August 4, 2014 Sorry me again - I didn't put the Smiley in the above reply!! It is supposed to say d (I actually said Big Dee neg but I don't want another Smiley)Anna AMcCord 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted August 5, 2014 Share Posted August 5, 2014 I agree with the above answers. Anti-Bga is not considered to be clinically significant, and I would not bother to titrate such a case. The Bga antigen is also very variable in strength; not just from one individual to another, but from a single individual over a period of time (so it is impossible to standardise the titration anyway). What I would do is to remove the Bga antigen from the red cells you have used to identify the antibody specificity (you can do this using a variety of chemicals - see any decent text book), just to ensure it really is anti-Bga, and not another specificity directed against a low prevalence antigen that just happens to be expressed on the red cells. If you really look for it (and you DON'T want to do this, as you will get bogged down in antibodies that have no clinical significance), you can find many HLA-related antibodies of various specificities in maternal plasma. As usual, I agree entirely with Anna's comments about the Rh problem. In another post, you were also asking about anti-K. You would use a couple of K+ red cell samples and sufficient K- red cell samples to rule out any other specificities. If you like to experiment, however, if you want to make "false Ko red cells", you can treat them with DTT or ZZAP, but be careful, as other blood group system red cells can also be weakened or completely disrupted by these chemicals. Link to comment Share on other sites More sharing options...
nick7791 Posted August 7, 2014 Author Share Posted August 7, 2014 question asked on paper: What is the first classic symptom of or acute and delayed transfusion reaction.and is there any test done when an patient has delayed transfusion reaction to confirm it. Thanks about anti Bga: i read it in technical manual that it may cause hemolytic disease of newborn. so if question asked if anti bga in pregnant patient still dont do any work up as it is clinically insignificant..?? thanks Link to comment Share on other sites More sharing options...
nick7791 Posted August 7, 2014 Author Share Posted August 7, 2014 (edited) 1 Edited August 9, 2014 by nick7791 Link to comment Share on other sites More sharing options...
nick7791 Posted August 7, 2014 Author Share Posted August 7, 2014 What cells are used as control for anti D serumis it R1R or R1R1 or R2R2 or rror something else..?? Link to comment Share on other sites More sharing options...
David Saikin Posted August 15, 2014 Share Posted August 15, 2014 rr and Ror (if possible); and a weak D+ cell and rr for weak D testing. Link to comment Share on other sites More sharing options...
nick7791 Posted August 31, 2014 Author Share Posted August 31, 2014 anti A - 0anti B - 2+mfanti D - 2+mfA cell - 0B cell - 0what can cause this reaction or what is the possible situation..?2)D - 0C - +E - 0c - +e - + what are the possible genotypes..? Link to comment Share on other sites More sharing options...
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