kylermt Posted May 28, 2012 Share Posted May 28, 2012 Hi to all!Can anyone please comment on the blood type with results below?Forward typing shows a blood type "A" with 4+ reaction but reverse gave:Test tube BT Known A - NEG Known B - NEGSince no agglutination seen, samples from the test tube were viewed under microscope (slide). Known A - Neg and Known B - Trace When samples on slide were again viewed under microscope after 10 to 15 mins : Known A - trace (with small aggregates) and known B - Trace Link to comment Share on other sites More sharing options...
Liz Posted May 28, 2012 Share Posted May 28, 2012 Please send:Age and gender of patient, diagnosis, history, previous Blood Group?? thanks Link to comment Share on other sites More sharing options...
kylermt Posted May 28, 2012 Author Share Posted May 28, 2012 Hi Liz,I'm afraid I wont be able to give you the details you needed. All I can say he's a donor. Link to comment Share on other sites More sharing options...
Liz Posted May 28, 2012 Share Posted May 28, 2012 Group A with weak anti-B, or Strong subgroup A with weak anti-A1 and weak anti-B.How does it react with anti-A1 lectin? Link to comment Share on other sites More sharing options...
Liz Posted May 28, 2012 Share Posted May 28, 2012 How are the reverse strengths in gel?what does his CBC look like? Link to comment Share on other sites More sharing options...
kylermt Posted May 29, 2012 Author Share Posted May 29, 2012 Hi Liz,Actually the sample was already sent to a reference laboratory coz the center where the blood came from doesn't have the capacity/capability to troubleshoot this kind of discrepancy. But until now, no update from the refernce laboratory. Im not sure if the sample was test in gel. kyle Link to comment Share on other sites More sharing options...
Liz Posted May 29, 2012 Share Posted May 29, 2012 ok, pls send a f/up when you get the resuts. Thanks Link to comment Share on other sites More sharing options...
Rh-fan Posted May 29, 2012 Share Posted May 29, 2012 Sounds like a chimera (the absence of anti B is nopt normal for a donor, for a patient it is seen more), where the brother or sister is B.I am interested in the folow up.Peter Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted May 29, 2012 Share Posted May 29, 2012 Sounds like a chimera (the absence of anti B is nopt normal for a donor, for a patient it is seen more), where the brother or sister is B.I am interested in the folow up.PeterIt is also worth remembering that a "twin" brother or sister can be entirely adsorbed by the surviving twin in utero, so, if this donor has no existing twin, it may still be worthwhile performing a karyotype to see if they are a chimera. Link to comment Share on other sites More sharing options...
John C. Staley Posted May 29, 2012 Share Posted May 29, 2012 How about an older patient/donor with a weak cold agglutinin. My matra has always been; rule out normal/common before going on a unicorn hunt. We really need more info. Link to comment Share on other sites More sharing options...
Rh-fan Posted May 29, 2012 Share Posted May 29, 2012 How about an older patient/donor with a weak cold agglutinin. My matra has always been; rule out normal/common before going on a unicorn hunt. We really need more info.I agree, in these kind cases first look to the age, but in this case it is a donor (so between 18 and 70), and a healty one also. So that is the reason for me to step over to the more unicorn.Last friday we had a pregnant woman with a group O, with strong anti A and no anti B (also not at 16oC). Today we performed absorption elution with anti B (a positive result) and a minor-cell population test (also positive). These results suggested a Group O with B chimera.Peter Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted May 29, 2012 Share Posted May 29, 2012 (edited) I agree John; I was just making a point about chimerism.I also KNOW that I am famous for chasing zebras?unicorns!!!!!!!!!!!!!!! Edited May 29, 2012 by Malcolm Needs Link to comment Share on other sites More sharing options...
kylermt Posted May 30, 2012 Author Share Posted May 30, 2012 Hi Guys,I'm happy that a lot of you are interested in this case. I'm new with this field and I appreciate your help. I will update you all as soon as I have the results.Kyle Link to comment Share on other sites More sharing options...
Nisar Posted May 30, 2012 Share Posted May 30, 2012 Hi to all!Can anyone please comment on the blood type with results below?Forward typing shows a blood type "A" with 4+ reaction but reverse gave:Test tube BT Known A - NEGKnown B - NEGSince no agglutination seen, samples from the test tube were viewed under microscope (slide). Known A - Neg and Known B - Trace When samples on slide were again viewed under microscope after 10 to 15 mins : Known A - trace (with small aggregates) and known B - Trace Link to comment Share on other sites More sharing options...
Nisar Posted May 30, 2012 Share Posted May 30, 2012 (edited) As the individual is a donor so you have to go through adsorption elution.we have a case exactly like that of a donor in previous years and when we did adsorption elution we found that the donor group was AB.ok take care:o.Nisar Edited May 30, 2012 by Nisar just make it clear Link to comment Share on other sites More sharing options...
kylermt Posted June 14, 2012 Author Share Posted June 14, 2012 Hi Guys,Sorry for the delay of my update re: the BT of the donor. The reference lab has difficulty of identifying the real blood type of the donor. They would like to have a fresh sample from the donor but unfortunately, the donor did not put any contact no. in the donor sheet.Anyway, thanks for all the feed backs I got from all of you. Greatly appreciated.Kyle Link to comment Share on other sites More sharing options...
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