clmergen Posted March 10, 2011 Share Posted March 10, 2011 Very nice Malcolm. Link to comment Share on other sites More sharing options...
L106 Posted March 10, 2011 Share Posted March 10, 2011 Hey!!! Way-to-go, Malcolm!!!! Link to comment Share on other sites More sharing options...
adiescast Posted March 10, 2011 Share Posted March 10, 2011 Good job Malcolm! I especially liked the part about scaring all of the Kell positive people into thinking they would become overweight tyrants who could not produce children.I don't know why they are chasing something other than syphillis as a cause for all of this, unless they do not believe that Henry had syphillis. It is absolutely possible that a venereal disease could cause many of the woes in this story. I thought that Henry also suffered from gout? That could certainly cause someone to be cranky... Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted March 10, 2011 Author Share Posted March 10, 2011 I thought that Henry also suffered from gout? That could certainly cause someone to be cranky...I'm sure you are correct, but I am doing a scientific experiment on that, and have been doing so for several years now, by being selfless enough to drink as much vintage port as possible to prove or disprove the theory!I wonder if getting cranky about this newspaper article is the first signs that the experiment is working, and that your assumption is quite right??????????!!!!!!!!!!!!!!!:crazy::crazy: Link to comment Share on other sites More sharing options...
adiescast Posted March 10, 2011 Share Posted March 10, 2011 Hmmm...are you having any other symptoms yet? Perhaps port was not Henry's vice of choice? You may want to add fatty foods to increase your chances of success in your experiment...You are certainly lined up with many great researchers in selflessly experimenting with your own body! Link to comment Share on other sites More sharing options...
TIrwin Posted March 14, 2011 Share Posted March 14, 2011 Ironically, (or maybe not ironically) I got a request from one of our hematologists last week to test his patient for the McLeod phenotype. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted March 14, 2011 Author Share Posted March 14, 2011 Ironically, (or maybe not ironically) I got a request from one of our hematologists last week to test his patient for the McLeod phenotype. Were there any symptoms to justify this? The reason I ask is that, with the modern monoclonal antibodies, the McLeod phenotype is sometimes not as easy to see as it used to be when we were using human-derived polyclonal antibodies. You can sometimes only detect it by titration of the monoclonal antibody using a known "normal" as a control, because the monoclonal antibodies are so strong when used neat. Link to comment Share on other sites More sharing options...
AMcCord Posted March 15, 2011 Share Posted March 15, 2011 Hmmm...are you having any other symptoms yet? Perhaps port was not Henry's vice of choice? You may want to add fatty foods to increase your chances of success in your experiment...You are certainly lined up with many great researchers in selflessly experimenting with your own body!A worthy endeavor - let us know how it turns out. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted March 15, 2011 Author Share Posted March 15, 2011 One thing I can tell you straight away - it's turning out to be blooming expensive!!!!!!!!!!!!!!!!:whew::whew: Link to comment Share on other sites More sharing options...
TIrwin Posted March 15, 2011 Share Posted March 15, 2011 Were there any symptoms to justify this? The reason I ask is that, with the modern monoclonal antibodies, the McLeod phenotype is sometimes not as easy to see as it used to be when we were using human-derived polyclonal antibodies. You can sometimes only detect it by titration of the monoclonal antibody using a known "normal" as a control, because the monoclonal antibodies are so strong when used neat.I don't think the history is very convincing. He has neuropathy and an elevated CK, but he also has diabetes and hypertension. I was told he had acanthocytes, but when I looked at the smear, it took me a while to find anything I'd even consider calling an acanthocyte, and it certainly wasn't a textbook appearance. Titration is not a bad idea though; we might try that anyway. Unsurprisingly he typed as K-k+ and we so rarely use our anti-k antisera that I wouldn't feel too guilty about using some more. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted March 15, 2011 Author Share Posted March 15, 2011 WOuld you mind letting us know your results please? Link to comment Share on other sites More sharing options...
TIrwin Posted March 15, 2011 Share Posted March 15, 2011 WOuld you mind letting us know your results please?Both the patient and the control reacted out to a dilution of 1:32. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted March 16, 2011 Author Share Posted March 16, 2011 Thanks TIrwin. It's certainly NOT the McLeod phenotype then!!!!!!! Link to comment Share on other sites More sharing options...
BrianD Posted March 23, 2011 Share Posted March 23, 2011 i'm trying to get a hold of the paper, interested to see what credentials the authors are holding. Link to comment Share on other sites More sharing options...
AMcCord Posted March 25, 2011 Share Posted March 25, 2011 i'm trying to get a hold of the paper, interested to see what credentials the authors are holding.That would be interesting...bet it's nothing to do with Blood Bank. Link to comment Share on other sites More sharing options...
Sarah Dickerson Posted March 25, 2011 Share Posted March 25, 2011 Three questions:1. How would you discover the K ab?2. This is my own ignorance - How many children were there? Which of the wives lived long enough to have more than one child. ;-OSarah Link to comment Share on other sites More sharing options...
adiescast Posted March 25, 2011 Share Posted March 25, 2011 There were three living children: Mary (of Catherine of Aragon), Elizabeth (of Anne Boleyn), and Edward (of Jane Seymour). Henry also had at least one illegitimate child. Catherine had a stillbirth (first pregnancy), two live births (died after a couple of months), and a miscarriage before Mary was born. Anne had a couple of still births or miscarriages after Elizabeth was born. Jane only had the one pregnancy. None of the other three queens had any reported pregnancies by Henry. Link to comment Share on other sites More sharing options...
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