Trm.40651

[kell23]

I was wondering how autologous units of patient's with an antibody should be handled. Is an AHG crossmatch needed? Does the unit need to be antigen tested if the patient has been antigen tested on their type and screen specimen? or can a 'historical typing' be used like the reference labs use. Any help is appreciated. Thanks.

[L106]

We deal with few autologous transfusions (maybe a couple a month), and our Lab staff rotate through the different lab sections. So for us, it is simplest and safety to just follow the one set of rules. That it, a patient with a clinically significant antibody must get a full crossmatch (ie: AHG), and the donor units must be tested and found to lack the corresponding antigen. (And, no, I would not use "historical" typing results on the autologous units.)

[Eagle Eye]

I think the intent behind doing crossmatch for autos is to make sure it's a right blood.

SO we follow same guidlines as allos....patient with antibody do AHG crossmatch & also do antigen typing on donor units.

[Lcsmrz]

We also do the same handling and crossmatching for all units, whether allogeneic, autologous or directed.

[SusanM]

We use the same guidelines for allo, auto, directed.

It's easier to have one set of rules & if you "shortcut" based on the autologous status of the unit, you are assuming there were no lableling errors... probably slim chance, but possible...

[LCoronado]

All blood units, whether allogeneic, autologous, or directed are treated identically here. All pretransfusion testing rules apply in all situations. In the event that there has been any error during the supplier's collection or processing of the blood, the patient will still be safe.

[adiescast]

We do the same, both antigen type and AHG crossmatch.