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QCDan

Anti-Viral interference

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Hello hive mind...

Anyone seeing interference from study drugs such as Remdesivir on antibody screen testing? We have seen some COVID + patients come up with weak reactivity in LISS and random (non-patterns) in solid phase. These patients were COVID+ and on a drug study for Remdesivir.

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I'm no longer working but if this is an antibody then it sounds logical that it could cause non-sp results…..

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Hi, Not aware of such kind of interference with nucleotide analog. It would be more likely if it was with convalescent plasma.

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These patients have a number of potential mechanisms for false positives.  Drug is one, and the others are excessive fibrin formation due to DIC and complement activation, which are both seen in seriously ill patients.  I assume you are not using anti-complement reagents in your antibody screening, so that is less likely.

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