QCDan 18 Posted April 2 Hello hive mind... Anyone seeing interference from study drugs such as Remdesivir on antibody screen testing? We have seen some COVID + patients come up with weak reactivity in LISS and random (non-patterns) in solid phase. These patients were COVID+ and on a drug study for Remdesivir. Share this post Link to post Share on other sites
galvania 763 Posted April 5 I'm no longer working but if this is an antibody then it sounds logical that it could cause non-sp results….. Share this post Link to post Share on other sites
Arno 41 Posted April 6 Hi, Not aware of such kind of interference with nucleotide analog. It would be more likely if it was with convalescent plasma. Share this post Link to post Share on other sites
Neil Blumberg 207 Posted April 9 These patients have a number of potential mechanisms for false positives. Drug is one, and the others are excessive fibrin formation due to DIC and complement activation, which are both seen in seriously ill patients. I assume you are not using anti-complement reagents in your antibody screening, so that is less likely. Share this post Link to post Share on other sites
