What we are seeing isn't so much "false positives" as it is weakly positive DAT's and strong cold antibodies. We think finding these is useful. We have seen some of the weak positive DAT's become strongly positive DAT's (escpecially in our oncology patients). If the patient has the strong cold antibody, we then know to use warm techniques, if necessary. Rarely, do we have a patient that there is no explanation. These tend to be the oncology patients and maybe it is some of the medications that they are receiving. What I like about the Echo is that we can run T/S's, Weak D's, and antibody id's all at the same time. We also run crossmatches on the Echo. We have also detected weak Anti-Jka's, Anti-Jkb's and Anti-E's on the Echo that are negative when tested manually. We think those are is very significant! Must be the red cell stroma!