Diane Lowitz

According to the package insert it states Bga, Bgb, Kna, Csa, Yka, JMH, McCa, Ch and Rg. My main concern is if a passive D is not honored in a transfusion to a neonate which is a premie will this cause any harm to the neonate who is rh positive? We do not have a maternity center at the hospital and rely on babies transferred to us for treatment. We do not see mom's specimen or have a history on mom to know if she received Rhogam . It is our policy to give type specific blood whenever possible. We preserve our Oneg blood for those who really need it.

It is stated in the Manufacture Insert as a limitation to the procedure. It states "Some IgG antibodies have shown to react poorly in solid phase red blood cell adherence assays. ...Passively administered antibodies may fail to react by Capture-R Ready Screen, even though the antibodies are detected by alternative technique." I also ran a screen plus panel using this methodology and it failed to detect the passive Anti-D.

We are in the process of validating the Capture-R Ready method (solid phase) with the intent of switching from Gel to the ECHO. I just discovered that passive anti-D is not detected in the Capture-R method. I am concerned that this passive anti D is not being picked up. We are a pediatric center and have always honored a passive anti-D when transfusing neonates. With Capture-R Ready method we will not be aware of a passive anti D and will transfuse RH positive red blood cells. This bothers me and I am not sure if this will affect the babies outcome. How do other facilities handle this or is this not an issue? Thanks in advance for any help.