We have a doc who's been notorious for giving RhIG a couple weeks prior to patient's due date and subsequent delivery. We have encountered 4+ rxns (tube) in these folks with previous negative ab screens. However we have never titered them out and attributed the reactivity to the RhIg. We have seen some of the same patients again at a later time with negative ab screens, so from our experience I'd say it is possible. I can not give you specific numbers though, just my recollections. And in answer to your question Shelby56, we indeed perform AHG crossmatchs.