Let's see if I can remember this from the days of leukoreduction decisions. There are different sets of HLA antigens (A,B,D,DR etc. I think). Plts only have the HLA A & B antigens, but wbcs have them all. In order to make antibody to the HLA A & B antigens, the recipient had to be exposed to the DR (I think) antigens as well, which meant that white cells were required. Once the antibodies were made, they could react with the plts causing refractoriness, but the wbc was necessary for the stimulation of the antibodies initially. Does anyone else remember if this is what the story was and whether it has been disproved or refined?