Bet'naSBB

My question would be - how strong was the pre-transfusion reactivity? If it was only 1-2+ in SP / and the patient isn't a "larger" person, I personally would suspect that the antibody titer was diluted to such a degree that SP did not pick it up anymore....... (but I REALLY don't like SP.....it's just too wishy-washy.....JMHO)

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Not sure that there is a specific number. We just validated some Grifols antisera and ran 20 comparisons.

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At our facility, we have to do a cold adsorption IF the cold auto interferes with the reverse and/or ISXM. Since testing with "neat" plasma is our standard of practice, we would still report the XM as incompatible and send it out with a release stating the incompatibility was due to an autoantibody. We are not "allowed" to prewarm away IS reactions. 🥶 IF we prewarm - it's only if the cold has a high thermal amplitude and causes interference after 37deg incubation / antiglobulin phase...........but that's just us.........

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Once our patients show panreactivity in GEL, we automatically switch them to PEG screens which are negative 95% of the time. We stop doing gel all together. We don't test with DTT treated cells until the PEG screen comes up pos. Then, if the screen is NEG with DTT treated cells, we give K neg units with a signed release.

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