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We only use it for antibodies that are unlikely to be clinically significant (an example would be anti-M) if they do not react at 37 and antiglobulin phase. Sometimes you find an anti-M that reacts weakly at 37, but not antiglobulin phase, and the prewarm makes it disappear at 37. In most cases, we would then ignore the antibody. Just some additional information to make clinical decisions. We wouldn't bother for antibodies usually capable of causing red cell destruction at body temperature. A strong cold with broad thermal amplitude up to 37 would not be much helped by pre-warming, so we use other techniques such as auto-adsorption to make it "go away." Thus we don't bother there with prewarming, just as we wouldn't be interested in making an anti-C or anti-Jka disappear by prewarming.
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5 ml/kg plus whatever amount is needed for the dead space, although they can flush that with crystalloid. One unit minimum perhaps. That's 15 ml/kg for a 1 kg premature newborn. Would suggest a maximum of 10 ml/kg. 5 unit pool would be about 75 ml/kg for a 1 kg neonate, a terrible over dose that would increase the risk of congestive heart failure due to volume, and thrombosis due to excessive fibrinogen and factor VIII in cryo. My advice is don't do that no matter how much your neonatologists want to do that. Potentially fatal. No possible therapeutic rationale.
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Hello ssnowy787, Welcome to PathLabTalk. Please feel free to browse around and get to know the others. If you have any questions, please don't hesitate to ask. ssnowy787 joined on the 05/06/2024. View Member
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Antigens This question was submitted by forum member, Malcolm Needs. Any errors are those of the site admin, not Malcolm. Submitter Cliff Category BloodBankTalk Submitted 05/06/2024
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How are you transfusing cryo to a neonate?. Issuing single cryo unit with filter? Pulling a syringe through a 150u filter starting with a 5 unit pool? Thanks for any information!
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