kmmoton Posted October 1, 2013 Share Posted October 1, 2013 Patient's antibody workup 4 months ago revealed Anti-e and Anti-C. Patient's blood type is historically O Pos and is the same on the current specimen. Current specimen antibody workup appears to be an Anti-D and Anti-C. With a positive Autocontrol and a negative DAT. Explanations please! Link to comment Share on other sites More sharing options...
John Eggington Posted October 1, 2013 Share Posted October 1, 2013 What's the diagnosis and what technique do you use for DAT? Link to comment Share on other sites More sharing options...
tbostock Posted October 1, 2013 Share Posted October 1, 2013 Female or male? Being treated for ITP? Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted October 1, 2013 Share Posted October 1, 2013 Are you certain that the anti-C and anti-e were alloantibodies in an R2R2, and not auto-antibodies in an R1R1, or that the anti-e (at least) wasn't an auto-antibody in an R2r, with the anti-C being an alloantibody all along? What is the ethnicity of the patient? That information would help too. DIII individuals are strongly D+, but often make anti-D, but are also G-, and can make an anti-C+G that can mimic an anti-C+D. Link to comment Share on other sites More sharing options...
kmmoton Posted October 1, 2013 Author Share Posted October 1, 2013 The patient is a Latin American female. The auto control was negative. DAT is also negative. The patient is an oncology patient. She hasn't received IvIg. Link to comment Share on other sites More sharing options...
John Eggington Posted October 2, 2013 Share Posted October 2, 2013 You've said the autocontrol is positive and negative, which is correct? Link to comment Share on other sites More sharing options...
galvania Posted October 3, 2013 Share Posted October 3, 2013 What is this patient's Rh phenotype? (DIV could also look like a normal D+ and make a nice anti-D) Has she received any blood or platelets in the last 4 months? Malcolm Needs 1 Link to comment Share on other sites More sharing options...
klsmith Posted October 19, 2013 Share Posted October 19, 2013 Was the patient transfused within the last 3 months?? Anti-C and Anti-D are actually an Anti-G. What is the Rh type of the patient? Link to comment Share on other sites More sharing options...
Auntie-D Posted October 22, 2013 Share Posted October 22, 2013 My first instinct was anti-G. I've seen it (once) Link to comment Share on other sites More sharing options...
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