Partial D

[Jaime]

I have an academic question to post. Does anyone know if the low incidence antigens (ex. BARC, FPTT, TAR) that are associated with partial D are located on the Rh protein? Are they neo antigens that are formed as a result of the gene mutations in partial D's ?

[Malcolm Needs ☆]

I have an academic question to post. Does anyone know if the low incidence antigens (ex. BARC, FPTT, TAR) that are associated with partial D are located on the Rh protein? Are they neo antigens that are formed as a result of the gene mutations in partial D's ?

The answer is, yes they are on the RhD protein, and yes, they are neo-antigens formed as a result of the gene mutations in partial D.

The amino acid residue substitutions alter the juxtaposition of all (or many) of the amino acid residues in the RhD protein (these juxtapositions being extremely important to the protein's expression).

There is a quite frighteningly good explanation for this (together with an elegant figure) in Geoff Daniels book Human Blood Groups, 2nd edition, 2002, Blackwell Science, in the chapter on Rh.

:D:D:D:D

[Liz]

Malcolm,

I do not cease to be impressed!!!

[Jaime]

Thank you, it really is a very good and clear explanation!

[Liz]

The book is very good too thank you for the ref.