Bet'naSBB Posted August 14, 2023 Share Posted August 14, 2023 (edited) Is everyone else having a difficult time finding suppliers that still collect CPDA-1 units? Or, is it just us here in Southeastern US? Edited August 14, 2023 by Bet'naSBB Link to comment Share on other sites More sharing options...
Neil Blumberg Posted August 15, 2023 Share Posted August 15, 2023 (edited) Our Red Cross just informed us that it will discontinue providing CPDA-1 rbc. We primarily used it to provide volume reduced red cells to pediatric patients under 3 years of age. We will volume reduce AS-1 or AS-3 by centrifugation or washing (Terumo 2991) instead. Probably unnecessary for most patients, but this is a long standing practice here, and it doesn't seem worthwhile trying to adjust pediatric practice in this regard. Most patients do not need the additional volume provided by the anticoagulant-preservative in AS-1, etc., and avoiding unnecessary volume is a reasonable goal in many patients. There is no inherent virtue to CPDA-1 vs. AS-1 and similar solutions, and rbc preservation is slightly better in AS-1/AS-3 by in vitro metrics. There is absolutely no factual basis for using CPD-A1 in preference to AS-1, etc. in pediatrics. Purely expert opinion and probably unduly conservative. I've attached a nice presentation by Dr. Saifee at the University of Washington, who createdAdditive solution AS-1 in Children Univ. Washington presentation Dec 2021.pptx it to educate her colleagues about using AS-1 instead of CPDA-1. Additive solution AS-1 in Children Univ. Washington presentation Dec 2021.pptx Pediatric RBC White Paper - November 2021.pdf Edited August 15, 2023 by Neil Blumberg Malcolm Needs, John C. Staley, Jsbneg and 6 others 9 Link to comment Share on other sites More sharing options...
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