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Everything posted by harev
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SCARF contact information
harev replied to Beth Eades's topic in Immunohematology Reference Laboratories
http://scarfex.jove.prohosting.com/ The site is active again......yeah! -
I suggest review of the literature regarding use of red cell products from donors with antibodies particularly the first reference from a large teaching facility. It is not uncommon to give out-of-group red cells which gives a much high-titiered antibody, anti-A, anti-B, anti-A,B, than would occur with use of red cells with unexpected atnibodies. Facilities in this area successfully use these products without problems. This avoids wasting products in particular Rh Negative red. About 50% of the antibodies found in donors are anti-D or anti-D + -C. 1. Combs MR, Bennett DH, Telen MJ. Large-scale use of red blood cell units containing alloantibodies. Immunohematology 2000; 16: 120-123. 2. Harbin K, Prihoda L. Alloantibody Titers in AS-1 Leukocyte-Reduces Donor Units. Transfusion 2003; 43: 32A (S105-040F). 3. Prihoda L, Spruell M, Sapp C, Plett M. Use of Donor Red Blood Cells Containing Alloantibody. Transfusion 2003; 43: 32A (S106-040F).
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Another consideration is that the donor has high-titered anti-A,B. Here is a report from my colleagues addressing this. Significant numbers of apheresis-derived group O platelet units have “high-titer†anti-A/A,B: implications for transfusion policy. Transfusion 2004; 44,805. When customers report suspected reactions to our blood center, we perform titers if they have not already been done, and if the donor has high-titered atni-A,B will defer the donor from donating plasma or platelets.
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"Methods in Immunohematology" by W. John Judd provides a procedure for preparation of IgG coated red cells. If you need it, send your email address.
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The May/June 2005 AABB News has a 2-page Q & A on TRALI.