I suggest review of the literature regarding use of red cell products from donors with antibodies particularly the first reference from a large teaching facility. It is not uncommon to give out-of-group red cells which gives a much high-titiered antibody, anti-A, anti-B, anti-A,B, than would occur with use of red cells with unexpected atnibodies. Facilities in this area successfully use these products without problems. This avoids wasting products in particular Rh Negative red. About 50% of the antibodies found in donors are anti-D or anti-D + -C. 1. Combs MR, Bennett DH, Telen MJ. Large-scale use of red blood cell units containing alloantibodies. Immunohematology 2000; 16: 120-123. 2. Harbin K, Prihoda L. Alloantibody Titers in AS-1 Leukocyte-Reduces Donor Units. Transfusion 2003; 43: 32A (S105-040F). 3. Prihoda L, Spruell M, Sapp C, Plett M. Use of Donor Red Blood Cells Containing Alloantibody. Transfusion 2003; 43: 32A (S106-040F).