Malcolm Needs

Sorry Neil, but I have to point out that this is not completely accurate. Any red cell antigens that are adsorbed onto the red cell surface, rather than being an integral part of the red cell membrane remain the type of the patient, rather than the donor. This is true of the Lewis phenotype (for instance, if the recipient was Le[a+b-], and the donor was Le[a-b+], after the transplant, the red cells will group as Le[a+b-], and not as Le[a-b+]}. This is also true of antigens within the Chido/Rodgers Blood Group System, and certain others. If the recipient is a Secretor, they will continue to secrete ABO substance of the original ABO type, which, of course, will also be adsorbed onto the red cell surface (as well as being in the plasma, leading to the phenomenon of "accommodation", and this is why most recipients stay with a reverse group of "AB" after an ABO mis-matched stem cell/bone marrow transplant. SORRY TO BE A PEDANT, PARTICULARLY AS I AGREE WITH EVERYTHING ELSE YOU HAVE WRITTEN!

I just answered this question. My Score PASS  

In the UK, the Guidelines would (quite correctly in my own opinion) NOT allow us to perform electronic issue on any sample, whatever the pathology, on a patient where the forward ABO type does not match the reverse ABO type (apart from Newborn babies).

Off the top of my head, as it were, the nearest source I can site is Hult AK, Dykes JH, Storry JR, Olsson ML. A and B antigen levels acquired by group O donor-derived erythrocytes following ABO-non-identical transfusion or minor ABO-incompatible haematopoietic stem cell transplantation. Transfusion Medicine 2017; 27: 181-191. DOI: 10.1111/tme.12411.

I just answered this question. My Score FAIL  

Welcome to this FABULOUS site mls2m. ENJOY!

Thank you very much Neil.

Welcome to this VERY SPECIAL site lauracls2004. ENJOY!!!!!!!!!!!!!!!!!!!!!!!

Welcome to this AMAZING site my good friend. ENJOY!!!!!

Neil Blumberg, I'll leave this one to you!

I just answered this question. My Score PASS  

I just answered this question. My Score PASS  

Welcome to this quite PHENOMENAL site StewPCam. ENJOY!!!!!!

The +s stands for strongly expressed. The expression of the P1 antigen varies considerably from person to person, but the reaction strength with anti-P1 is an inherited trait (i.e. the strength of the expression on the red cell surface). "I apologize for this dumb question." BBnoob69, NO QUESTION IS A DUMB QUESTION, IF YOU DO NOT KNOW THE ANSWER. If you don't know the answer, the dumb thing is to not ask the question in the first place. NEVER be afraid to ask a question on here,

Welcome to this WONDERFUL site vavalos. ENJOY!!!!!!!

I just answered this question. My Score FAIL  

Welcome to this PHENOMENAL site bankerbob. ENJOY!

I just answered this question. My Score PASS  

Welcome.

Welcome to this AMAZING site JulesD, ENJOY!

Welcome to this FANTASTIC site Mamajf100. ENJOY!

Hi Rich, Yes you can, and, don't forget, under BSH Guidelines, you do not have to give blood that has been tested for the Cw antigen, if the unit is compatible by IAT with the patient's plasma/serum. It is one of the few Rh antigens that can be given under these circumstances. Be aware though, that I answer this in the knowledge that you are working in the Isle of Man (i.e. the UK). This may not apply in other parts of the world (particularly Lithuania and Finland).

ALL Rh antibodies react with red cells treated with proteolytic enzymes, such as ficin, papain, trypsin and alpha-chymotrypsin (well, red cells that are expressing the cognate antigen, anyway), BUT, be careful because most monoclonal grouping reagents, including monoclonal anti-Cw, will often say to be used by either direct agglutination or by IAT, BUT NOT to be used with enzyme-treated red cells, because they can cause false positives. Most of what I have written above can be found in Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook. 3rd edn, 2012. Academic Press. ISBN: 978-0-12-415849-8. The rest can be found in the manufacturer's insert, if the reagent is commercial. Hope that helps, but feel free to get back if it doesn't.

I just answered this question. My Score PASS Total guess on my part!!!!!!!!!!!!!!!!!!!!!!!!!!

Welcome to this BRILLIANT site labgal. ENJOY!!!!!!!!