Posts posted by Malcolm Needs
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11 hours ago, jtemple said: I have never understood why we are using DDT instead of trypsin? I do realize that DDT is somewhat easier to use than trypsin, but the Kell problem is eliminated. M & N require looking at, but I will take that trade. In the Southeast we also look out for Jsb as quite a few Jsb- people live here.
Um, sorry Jason, but I think you mean Dithiothreitol (DTT), rather than Dichlorodiphenyltrichloroethane (DDT)!!!!!!!
- Yanxia, Darin and John C. Staley
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2 hours ago, Neil Blumberg said: Also, were any of the transfused units antigen positive? This is the quickest way to get a negative indirect antiglobulin test ;).
AGREED - and killing the patient in some circumstances!!!!!!!!!!!!!!!!!!
- bblover and John C. Staley
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I agree Darin, it is almost certainly a dilutional effect, BUT, it could also be the effect of a soluble antigen (obviously not within the Duffy Blood Group System). If the antibody had a specificity within, for example, the Lewis Blood Group System, or the Chido/Rodgers Blood Group System, the antigen in the plasma could well adsorb out the circulating antibody. That having been said, this explanation is FAR less likely than your suggestion of the dilutional effect.
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General Lab: Pox virus
in Question of the Day