After making sure that all the antibodies for which commercial antisera is readily available have been ruled out (with a double dose cell if at all possible), repeating the gel tests with longer incubation and doing a gel xm, we transfuse. Occasionally I drop back to LISS when I am convinced I am dealing with a weak warm auto or HTLA-like antibody. I work really hard to rule out Kidd system antibodies because weak ones often won't react with one cell that they should but the only cells reacting are pos for the Ag and the patient is neg. I don't worry so much about non-Kidds. I will admit, if even Kidds are that weak, they still probably won't do that much damage. Kidd has such a reputation, I'm careful, but I have never seen it do its delayed TRX thing.