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Maybe choloroquine phosphate can help to remove the IgG antibodies on the cells surface. And heat elution (45 degree C 15 min or 56 degree C 10 min) can do some help to remove IgG antibodies, but not as effective as to IgM antibodies.

I was wondering if anyone had any information regarding an Anti-Can? In Marion E. Reid & Christine Lomas-Francis's "Blood Group Antigens and Antibodies" guide, they reference an 'Anti-Can' which reacts like an Anti-M but mostly with Black donors vs Caucasians. However I am unable to find any more information regarding this antibody. Would greatly appreciate any input or any further reading materials that mention this antibody. Thanks!

The Can antigen is now one of those included in the MN CHO Blood Group Collection (see Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook. 3rd edition, 2012, Academic Press). These antigens/antibodies are NOT considered to be of clinical significance whatsoever, in terms of either transfusion reactions or HDFN, but It may be that GlnNAc-containing O-glycans confer a selective advantage against invasion by Plasmodium falciparum merozoites, which may explain why the antigen is found more frequently in Black individuals than White.

Our policy is if the patient is transfused they get a new ABID every 3 days but if the patient is not transfused we will only do the ABID if they are going to be transfused or every 7 days which ever comes first. Being at a children's hospital we don't get a lot of antibodies and most of them are WAA from our oncology/hematology kids. Plus we don't have the staff to complete the WAA workups ourselves and they get sent to a reference lab. So if they are just keeping a current TSCR but are not planning on transfusing (usually they give medication instead of transfusing these WAA kids) we only send out the ABID if they want blood for a procedure or something. We also keep the kids on the same unit and/or donor as long as possible. That's the nice thing about kids. For those kids with other than WAA we do a new ABID with every sample. For neonates (passive antibodies) we do a new ABID when we run out of specimen to crossmatch new units which happens rarely.