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Thank you kjmiller. Could be the doctor is being more cautious/more proactive, but in the UK (and I have only ever worked in the UK) our Guidelines suggest/DEMAND that we give K Negative to a patient requiring chronic transfusion, unless they are K Positive (although, interestingly, they are silent on what to give if the patient is K+k-!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!).

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Good morning, Malcom. Thanks for your reply- she is 61 yrs old and KNeg. I agree also with your approach, but we also have lots of patients with chronic anemias on transfusion support for whom we aren't giving K Neg. Maybe the dr. is just being more proactive in this case.

The first thing I would ask is, is the lady pre- or post-menopausal? That having been said, in the UK, we tend to give all patients who are likely to be chronically transfused, K Negative blood, whether they be male or female, unless, of course, they are known to be K Positive, purely because the antigen is so immunogenic. As for your question regarding irradiation, that is much more of a clinically decision (I am not, and never have been a Clinician), but I can't see why the units should not be irradiated,

We have a patient with autoimmune aplastic anemia and hx of anti-E. This is our first time seeing her, and current ABSC and ABID are pan-reactive due to WAA. The autocontrol and DAT ( both IgG and C3) were positive and WBC count = 1.5 K/ul. Pre-transfusion Hgb was 6.2 and over last 2 days has rec'd 2 units of E-neg "least incompatible" RBCs. Her Heme Onc is now requesting all add'l units be both E-negative and K-negative. I was not able to reach her directly, but curious why she's requesting K-neg. Anyone see the connection? All I can think of is she doesn't want to risk alloimmunizaiton to K (we do phenotypically match C, E, K, Fya/b, and S for sickle patients), but wondering if there's another indication in this situation. (Also, why not irradiated given her current white count?). Thanks for any insight!

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For acquired maternal IgG antibodies (which may also be transferred postnatally through breast milk), assessing the antibody specificity (AbS) in the newborn, as previously mentioned, appears to be a reasonable approach. In addition, the Direct Antiglobulin Test (DAT) remains key, and performing an elution is important (even if the DAT result is negative). In your case, the negative DAT suggests that either the anti-N antibody did not cross the placenta, possibly due to being a naturally occurring IgM, and/or the baby is N-negative.

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Sclerotic bodies This question and answer was originally published on Lab Tests Guide. They have generously permitted us to repost here on our site. This site's admin may have slightly modified the questions and answers. Please consider visiting their site: https://www.labtestsguide.com/ Submitter Cliff Category General Lab Submitted 07/04/2025  

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