Delayed Transfusion Reaction, anti-C

[Malcolm Needs ☆]

Ah, that explains it goodchild.

e variant (which you told us about) and I went down the road of anti-HrB or anti-HrS at one point.

I really should have thought of anti-hrB or anti-hrS (rather than the upper cases "H"'s).

In the case of both anti-hrB and anti-hrS, although the antibody is, if you like, directed against a bit of the "normal e antigen" (rather like the anti-D in a D variant is directed against a "bit of the D antigen that is missing" (actually a "normal bit of the D antigen" that the patient lacks, because of a mutation), the antibody seems to react more strongly with Ce+ red cells than either C-e+ red cells, or C+e- red cells, which would explain the apparent anti-C.

The other antibody specificities served to throw me a bit; and they shouldn't have done. Smack on the wrist for me!

Really great Case Study. Thank you!